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Pleural effusion disease in rabbits. Interferon in body fluids and tissues after experimental infection



Pleural effusion disease in rabbits. Interferon in body fluids and tissues after experimental infection



Acta Pathologica et Microbiologica Scandinavica. Section B, Microbiology 87(5): 311-315



Distribution of interferon in body fluids and tissues was studied in 18 rabbits infected experimentally with the agent of pleural effusion disease (PED) [believed to be a virus]. Circulating interferon of the classical type was demonstrable 12 h after inoculation, and a maximum response was attained 2-3 days later. Circulating interferon disappeared 6-8 days after inoculation. Interferon titers of serum were closely correlated with the early phase of febrile response and probably with the initial growth phase of the PED agent. Interferon titers of pleural fluid exceeded by far the titers of other body fluids and tissues. No interferon could be demonstrated in brain, liver and urine.

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Accession: 006135868

Download citation: RISBibTeXText

PMID: 525355

DOI: 10.1111/j.1699-0463.1979.tb02444.x



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