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Pleuropneumonia caused by haemophilus pleuropneumoniae haemophilus parahaemolyticus in swine iv. treatment and drug resistance of hungarian isolates



Pleuropneumonia caused by haemophilus pleuropneumoniae haemophilus parahaemolyticus in swine iv. treatment and drug resistance of hungarian isolates



Magyar Allatorvosok Lapja 41(7): 395-399



Drug resistance of 40 Hungarian Haemophilus pleuropneumoniae strains was tested by disc method (Table 1). The strains were isolated on 24 large-scale swine farms. On the basis of the diameter of zones of inhibition, 5 each strains were selected and their MIC-values were also determined (Table 2). In the case of some chemotherapeutics, the results of in vitro investigations were compared with the results of treatments under practical conditions. In contrast to the majority of literature data, 90 to 100% of the strains proved to be resistant to penicillin and penicillin derivatives (methycillin, oxacillin, ampicillin, carbenicillin). Streptomycin resistant strains were not isolated (although 55% of isolates were moderately sensitive to streptomycin). Practically all (or nearly all) the strains were resistant to cephalosporin, oleandomycin, spiramycin, bacitracin, vancomycin, novobiocin and also to Superseptyl. It has not been found any strain resistant to the following chemotherapeutics: streptomycin, neomycin, spectinomycin, gentamycin, chloramphenicol, tylosin, chlorotetracyclin, polymyxin B, tiamulin, nitrofurantoin. However, the rate of strains sensitive and moderately sensitive to these chemotherapeutics varied between a broad range. All the strains were highly sensitive only to chloramphenicol and nitrofurantoin. The rate of moderately sensitive strains was especially high in the case of streptomycine, spectinomycin, erythromycin, tylosin, lincomycin, tetracyclines and thiamulin. The lowest MIC-values were found in the case of neomycin, chloramphenicol, tetracyclines, nitrofurantoin and Sumetrolim (a potentiated sulfonamide). The results of treatments under practical conditions corresponded well to the results of in vitro antibiotic resistance tests. The best results were obtained by individual parenteral treatments (with chloramphenicol). Favourable results were also obtained even when the affected animals with clinical symptoms were individually treated and their litter mates were treated via the drinking water (Tylan, Dynamutilin). When many cliniclly affected swine were in the stock, only moderate results were obtained by medicated feeds (Erra-6, Tylan premix, Trierra, Tylan-Furazolidon).

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