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Post therapeutic acute malignant myelo proliferative syndrome and acute nonlymphocytic leukemia in non hodgkins lymphoma correlation with intensity of treatment


Cancer 50(11): 2285-2288
Post therapeutic acute malignant myelo proliferative syndrome and acute nonlymphocytic leukemia in non hodgkins lymphoma correlation with intensity of treatment
In a prospective randomized study of treatment with radiation therapy (RT) or RT + chemotherapy (CT) [1,3-bis-(2-chloroethyl)-1-nitrosourea, nitrogen, mustard, cyclophosphamide, vincristine, prednisone] for patients with non-Hodgkin's lymphoma Stages I-III, 1 patient developed an acute malignant myeloproliferative syndrome (AMMS) and 4 others acute nonlymphocytic leukemia (ANLL). There was correlation between the intensity of treatment and development of this complication. Among patients treated with local radiation with or without chemotherapy no cases of AMMS or ANLL were observed. However, patients treated with total lymphoid irradiation alone (TLI) had an observed to expected ratio of 162. Among patients treated with TLI plus CT this ratio increased to over 1000. The cytogenetic, clinical and hematologic abnormalities of these patients are discussed.

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Accession: 006153408



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