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Post transfusion cytomegalovirus and newborn infants infection and prevention



Post transfusion cytomegalovirus and newborn infants infection and prevention



Revue Francaise de Transfusion et Immuno-Hematologie 27(3): 345-354



More severe post-transfusion cytomegalovirus infections (PTCMV) develop in infants born of uninfected mothers (CMV seronegative mothers). These newborns have no passively acquired maternal antibodies which probably prevent or limit the spread of PTCMV infection in infants born of CMV seropositive mothers. Almost all transfused newborns are premature and many of them receive > 10 micro-transfusions of red blood cells. Thus, their risk of developing CMV infection is high (10-20%). The limited immune competence of these newborns and the fact that many already suffer from other developmental defects explain the severity of these PTCMV infections. Prevention of PTCMV infections is possible by using blood from CMV seronegative donors. Frozen blood also appears effective.

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Accession: 006153488

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