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Post translational processing of trh precursor in rat brain identification of 3 novel peptides derived from pro trh



Post translational processing of trh precursor in rat brain identification of 3 novel peptides derived from pro trh



Brain Research 456(1): 22-28



The sequence of rat hypothalamic pro-thyrotropin releasing hormone, deduced by sequencing of cDNA, in addition to 5 TRH progenitor sequences contains leader, trailer and 4 intervening sequences separated by paired basic amino acid sequences. We have developed radioimmunoassays to synthetic peptides corresponding to portions of these cryptic pro TRH sequences and have used these assays to identify and partially characterize pro TRH peptides, distinct from TRH, in extracts of rat brain. Two of these peptides correspond closely in size to one intervening sequence and the carboxy-terminal sequence of pro TRH. Three other peptides corresond to the intact amino-terminal leader sequence and two peptides formed by a further cleavage of the leader sequence at an internal paired basic amino acid sequence.

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Accession: 006153608

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