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Postantibiotic effect of imipenem on Pseudomonas aeruginosa


Antimicrobial Agents and ChemoTherapy 26(5): 678-682
Postantibiotic effect of imipenem on Pseudomonas aeruginosa
Imipenem (formerly N-formimidoyl thienamycin) and ceftazidime were investigated for their postantibiotic effect on Pseudomonas aeruginosa. Four strains of P. aeruginosa in the logarithmic phase of growth were exposed for 1 and 2 h to concentrations of antibiotics achievable in human serum. Recovery periods of test cultures were evaluated after dilution or addition of .beta.-lactamase. A consistent postantibiotic effect against all strains was obtained with imipenem but not with ceftazidime. Although ceftazidime did not have a postantibiotic effect, it did suppress the growth of the organisms at concentrations equivalent to 1/3 of the MIC [minimal inhibitory concentration]. The clinical implications of these effects need further evaluation.


Accession: 006153890

PMID: 6440477

DOI: 10.1128/aac.26.5.678



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