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Postcesarean microbiology of high risk patients treated for endometritis

Postcesarean microbiology of high risk patients treated for endometritis

Current Therapeutic Research 42(6): 1157-1165

The microbiology of postpartum endometritis that developed in high-risk patients delivered by cesarean section was studied. The patients required antimicrobial therapy and received regimens of either mezlocillin, cefoxitin, or clindamycin plus gentamicin as part of a clinical comparative study. There was a close parallel between pathogens isolated from the endometrium and blood of bacteremic patients. The patient population studied exhibited a relatively high rate (29%) of unimicrobial infections, but the predominant organisms isolated were the same in unimicrobial and polymicrobial infections. Mezlocillin demonstrated good in vitro activity against the most commonly isolated pathogens. However, the correlation between clinical failure or success and recovery of resistant organisms was not always apparent in the three treatment groups.

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Accession: 006153924

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