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Postinfarction sudden death: significance of inducible ventricular tachycardia and infarct size in a conscious canine model



Postinfarction sudden death: significance of inducible ventricular tachycardia and infarct size in a conscious canine model



American Heart Journal 109(1): 8-18



The relationship between inducible ventricular tachycardia in the convalescent phase of myocardial infarction and subsequent spontaneous ventricular fibrillation is uncertain. Thirty conscious instrumented dogs underwent programmed ventricular stimulation 5 days after anterior infarction; 15 had inducible ventricular tachycardia and 15 were noninducible. Following programmed ventricular stimulation, the application of a 150 .mu.A current to the intima of the proximal circumflex artery initiated intimal damage, thrombosis and acute ischemia of the posterolateral wall. After 20 min of ischemia, 73% inducible and 15% noninducible animals developed ventricular fibrillation (P < 0.005) without previous hypotension. At 24 h, 7% inducible and 85% noninducible animals survived (P < 0.001). Anterior infarct size (percentage of left ventricular mass) was much larger in inducible (24.7 .+-. 1.7%) than in noninducible (5.3 .+-. 1.1%) (P < 0.001) animals. Inducible ventricular tachycardia following infarction was highly predictive of spontaneous ventricular fibrillation during a later ischemic episode in this model. The mass of previously injured myocardium was a critical determinant of both.

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Accession: 006154449

Download citation: RISBibTeXText

PMID: 3966335

DOI: 10.1016/0002-8703(85)90409-0


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