Postsynaptic phosphatidyl inositol effect of nerve growth factor in rat superior cervical ganglia

Lakshmanan, J.

Journal of Neurochemistry 32(5): 1599-1602


ISSN/ISBN: 0022-3042
Accession: 006155442

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Neurotransmitters, hormones and drugs are known to elicit an increased turnover of phosphorylinositol group of phosphatidylinositol (PI) in various tissues. This effect is often referred to as 'PI-effect' or 'inositide-effect'. Recently, nerve growth factor (NGF) has been shown to elicit a PI-effect in rat superior cervical ganglia (SCG). In order to ascertain the site at which NGF elicits the stimulation of PI-turnover, SCG from decentralized rats were used. Since preganglionic denervation of SCG in rats was reported to decrease the activity of acetylcholine esterase, the activity of this enzyme was measured in SCG of decentralized and sham-operated rats. Results provided evidence that NGF elicits an inositide-effect similar to that in sham-operated animals. Thus it appears that the post-synaptic structures are the primary locus at which NGF elicits the PI-effect in rat SCG.