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Pre dosing plasma concentrations and beta adrenoceptor blocking effects during repeated once daily dosing with 160 milligram sustained release propranolol inderal la and 16 260 oxprenolol oros to healthy volunteers



Pre dosing plasma concentrations and beta adrenoceptor blocking effects during repeated once daily dosing with 160 milligram sustained release propranolol inderal la and 16 260 oxprenolol oros to healthy volunteers



British Journal of Clinical Pharmacology 19(SUPPL 2): 197S-202S



Plasma drug concentrations and attenuations in sub-maximal exercise tachycardia were measured in 6 healthy subjects 24 after the 3rd and 4th doses of Inderal LA and 16/260 oxprenolol Oros administered once dialy. Both drugs significantly reduced exercise heart rates relative to the placebo response at both observation times. The mean percentage reductions on the 3rd and 4th days were, respectively, 15.7 and 11.6% for Inderal LA compared with 18.1 and 12.2% for 16/260 oxprenolol Oros. The differences between formulations were not statistically significant. The mean plasma concentrations at 24 h on the 3rd and 4th day were 119 and 101 ng/g for oxprenolol and 16.2 and 15.8 ng/g for propranolol.

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Accession: 006160128

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