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Predictability of immunologic phenotype of malignant lymphomas by conventional morphology a study of 60 cases



Predictability of immunologic phenotype of malignant lymphomas by conventional morphology a study of 60 cases



Cancer 43(4): 1216-1224



To test the immunologic validity of the Lukes-Collins (L-C) classification of the non-Hodgkin's lymphomas (ML), 60 ML in adult patients were studied and their [bone marrow-derived] or T [thymus-derived] -cell nature was predicted on a morphologic basis, without knowledge of the clinical history or the results of surface marker (SM) studies (SIg [surface immunoglobulin], C' [complement], Fc and E [erythrocyte] rosettes), which were performed on cell suspensions and cryostat sections from the same specimens used for histology. There was a good correlation between morphologic types and SM (97% for the nodular ML, 81% for the diffuse). The predictions were not confirmed in 6 instances: 1 nodular ML typed as T; 1 convoluted lymphocytic ML typed as histiocytic and 4 diffuse ML, predicted to be of B type, bore no detectable SM (null ML). The L-C morphologic criteria allow in most cases the recognition of the B or T cell nature of ML, but cannot detect variations of the SM pattern which affect the clinical behavior of these neoplasia. While the L-C classification seems immunologically sound, its clinical relevance still needs to be demonstrated.

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Accession: 006163204

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PMID: 376087

DOI: 10.1002/1097-0142(197904)43:4<1216::aid-cncr2820430409>3.0.co;2-f


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