+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of deuterated pteroyl glutamic acid by acid catalyzed exchange with deuterium oxide

, : Preparation of deuterated pteroyl glutamic acid by acid catalyzed exchange with deuterium oxide. Journal of Labelled Compounds and Radiopharmaceuticals 14(4): 479-486

Pteroylglutamic acid was labeled with 2H by trifluoroacetic acid-catalyzed exchange with deuterium oxide. The product, pteroylglutamic acid-3',5'-2H2, was selectively labeled with 2H in the 4-aminobenzoyl portion of the molecule; there was no evidence for isotope incorporation at C7 or C9 of the pteridine ring or at the glutamate residue. Isotope composition of the pteroylglutamates was determined by chemical ionization mass spectrometry following a base-catalyzed, oxidative cleavage to either 4-aminobenzoic acid or 4-aminobenzoylglutamic acid. Products from the exchange reaction typically contained 1% 2H0, 9% 2H1 and 90% 2H2 isotopic species.

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006173036

PDF Full Text: Submit

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Redenbaugh K.; Ruzin S.; Bartholomew J.; Bassham J.A., 1982: Characterization and separation of plant protoplasts via flow cytometry and cell sorting. Large populations of protoplasts from 5 spp., Euphorbia lathyris, Nicotiana glauca, N. langsdorfii, Petunia parodii and P. inflata (albino) were characterized by flow cytometry on the basis of laser light scatter and chlorophyll fluorescence or ex...

Singh, M.; Periasamy, A., 1984: Determination of safe exposure levels of He/Ne laser light to the human body by means of erythrocyte irradiation studies. Medical & Biological Engineering & Computing 22(2): 147-150

KHARON, N.S., 1959: Roentgen therapy of infectious encephalitis. Vestnik Rentgenologii i Radiologii 34: 3-6

Liu, L.F., 1989: DNA topoisomerase poisons as antitumor drugs. Herpes simplex virus type 1 was isolated from the cerebrospinal fluid of a patient during the first attack of multiple sclerosis. This is the first virus to be isolated from the central nervous system of a living patient with MS. The virus was ide...

Balner H., 1972: Chimpanzee breeding and management at the primate center tno. Goldsmith, Edward I. Moor-Jankowski (ed.). Medical Primatology: Basel, Switzerland; New York, N.y., U.s.a. 81-87

Chorn, R.; Parekh, A., 1997: Adolescent sexual offenders: a self-psychological perspective. Following a request for assistance in formulating a treatment philosophy for adolescent sexual offenders, a qualitative study of seven adolescent offenders was designed with a view to elaborating pre-offense, and post-offense dynamics. The point o...

Torres, R.; Pereira, E.; Vasconcelos, Vítor.; Teles, Lís.Oliva., 2011: Forecasting of cyanobacterial density in Torrão reservoir using artificial neural networks. The ability of general regression neural networks (GRNN) to forecast the density of cyanobacteria in the Torrão reservoir (Tâmega river, Portugal), in a period of 15 days, based on three years of collected physical and chemical data, was assesse...

Sege D.; Knoblauch A., 1984: Surgery for bullous pulmonary emphysema. Helvetica Chirurgica Acta 51(2): 257-260

Xiong, J.; Zhu, Z.; Liu, J.; Wang, Y.; Li, Z., 2006: Role of protease activated receptor-2 expression in renal interstitial fibrosis model in mice. The role of protease activated receptor-2 (PAR-2) in the renal tubulointerstitial lesion induced by unilateral ureteral obstruction (UUO) was explored. Mice were sacrificed on the day 1, 3, 5, 7, 10, 14 and 21 after UUO. The expression of PAR-2 mR...

Thapar, G. S., 1968: Some new larval strigeids causing black spot disease in fishes from Tungabhadra dam. 3 new species of Strigeidae causing black spot disease were recovered from freshwater fish taken at Tungabhadra, India, and are described and illustrated. Diplostomulum nurius n.sp. from Nuria daurica is distinguished from other species of this ge...