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Preparation of di hydro carminomicin and comparison of its anti tumor activity to activity of carminomicin

Preparation of di hydro carminomicin and comparison of its anti tumor activity to activity of carminomicin

Antibiotiki (Moscow) 21(11): 1008-1011

A dihydro derivative of carminomycin was prepared using chemical reduction with potassium borohydride. When dihydrocarminomycin was administered i.v. to healthy albino mice in a single dose it practically showed the same toxicity as carminomycin. Unlike the latter dihydrocarminomycin induced death of the animals at later periods of time. Studies in mice with transplantable tumors showed high antitumor activity of dihydrocarminomycin against lymphosarcoma L10-1, sarcoma 180, Harding-Passy melanoma, L1210 lymphoid leukemia and P-388 lymphocytic leukemia. In treatment of mice with L-1210 leukemia and Harding-Passy melanoma dihydrocarminomycin was inferior to carminomycin.

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Accession: 006173048

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