EurekaMag.com logo
+ Site Statistics
References:
53,214,146
Abstracts:
29,074,682
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of di hydro carminomicin and comparison of its anti tumor activity to activity of carminomicin






Antibiotiki (Moscow) 21(11): 1008-1011

Preparation of di hydro carminomicin and comparison of its anti tumor activity to activity of carminomicin

A dihydro derivative of carminomycin was prepared using chemical reduction with potassium borohydride. When dihydrocarminomycin was administered i.v. to healthy albino mice in a single dose it practically showed the same toxicity as carminomycin. Unlike the latter dihydrocarminomycin induced death of the animals at later periods of time. Studies in mice with transplantable tumors showed high antitumor activity of dihydrocarminomycin against lymphosarcoma L10-1, sarcoma 180, Harding-Passy melanoma, L1210 lymphoid leukemia and P-388 lymphocytic leukemia. In treatment of mice with L-1210 leukemia and Harding-Passy melanoma dihydrocarminomycin was inferior to carminomycin.

(PDF 0-2 workdays service: $29.90)

Accession: 006173048



Related references

Comparison of the anti tumor immuno depressant and toxic properties of carminomicin albumin complexes differing in carminomicin content. Antibiotiki (Moscow) 26(4): 298-302, 1981

Comparative studies on cardio toxicity of the anthracycline antibiotics rubomycin carminomicin and di hydro carminomicin in experiments on albino mice. Antibiotiki (Moscow) 23(1): 78-87, 1978

Production of 14 oxy carminomicin and study of its anti tumor activity. Antibiotiki (Moscow) 22(8): 693-695, 1977

Anti tumor activity of the antibiotic carminomicin administered orally. Antibiotiki (Moscow) 21(11): 1005-1007, 1976

Studies on anti tumor activity of carminomicin in children with malignant tumors preliminary report. Antibiotiki (Moscow) 21(7): 654-657, 1976

Comparative characteristics of anti tumor and immuno depressive activity of carminomicin in experimental model l 1210. Antibiotiki (Moscow) 24(10): 767-771, 1979

Molecular pharmacological differences between carminomicin and its analog carminomicin 11 methyl ether and adriamycin. Cancer Research 40(2): 387-294, 1980

Effect of medium ph on the growth of carminomicin producer and biosynthesis of the carminomicin complex. Antibiotiki (Moscow) 22(5): 387-391, 1977

Anti neoplastic activity of carminomicin complex components. Antibiotiki (Moscow) 22(1): 69-74, 1977

Anti leukemic activity of carminomicin complexes with high polymer dna. Antibiotiki (Moscow) 25(6): 454-458, 1980