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Preparation of difluorophosphonoacetic acid and its derivatives

, : Preparation of difluorophosphonoacetic acid and its derivatives. Journal of Organic Chemistry 53(7): 1523-1527

The preparation of ethyl difluoro(diethoxyphosphinyl)acetate (1) has been effected by the acylation of [(diethoxyphosphinyl)difluoromethyl]zinc bromide with ethyl chloroformate in the presence of a catalytic amount of cuprous bromide. Similarly prepared were ethyl dilfuoro)diethoxyphosphinyl)pyruvate (2) and N,N-diethyldifluoro(diethoxyphosphinyl)acetamide (3). Bromotrimethylsilane selectively reacted with 1 to yield ethyl difluoro[bis(trimethylsiloxy)phosphinyl]acetate (9).The remaining ethyl carboxylic ester of 9 reacted with iodotrimethylsilane to produce trimethylsilyl difluoro[bis(trimethylisiloxy)phosphinyl]acetate (10), which was subsequently hydrolyzed to yield difluorophosphonoacetic acid (8). The phosphonate 9 was gently chlorinated to yield ethyl difluoro(dichlorophosphinyl)acetate (11).

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Accession: 006173055

DOI: 10.1021/jo00242a034

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Jorgensen A.; Overo K.F., 1971: The distribution pattern of a series of thymoleptics compared to their lipid solubility and binding to plasma proteins. Acta Pharmacologica et Toxicologica Supplementum 29(SUPPL 4): 24

Mervis, J., 1994: NSF gears up for a building boom. Science 265(5178): 1516-1518

Baldassari, N.; Martini, A.; Baronio, P.; Fiumi, G.; Rama, F.; Capizzi, A., 1996: Captures of carpophagus Lepidoptera of chestnut by specific synthetic sexual attractants and response of other Lepidoptera: Oecophoridae, Tortricidae, Thyatiridae, Geometridae and Lymantriidae. The efficacy of eight attractants prepared to evaluate populations of carpophagus Lepidoptera of chestnut was studied at seven locations in the Appennines of Tuscany and Romagna, Italy. Among the species caught were Pammene fasciana, Cydia fagigla...

Suzuki, H.; Okihara, K.; Miyake, H.; Fujisawa, M.; Miyoshi, S.; Matsumoto, T.; Fujii, M.; Takihana, Y.; Usui, T.; Matsuda, T.; Ozono, S.; Kumon, H.; Ichikawa, T.; Miki, T.; Takeda, M.; Inoue, T.; Fujimoto, N.; Uemura, M.; Mugiya, S.; Kinoshita, H.; Nasu, Y.; Saika, T.; Ishi, M.; Matsubara, A.; Tacho, T.; Yano, A., 2008: Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade. Purpose: Large meta-analyses have documented that maximum androgen blockade with nonsteroidal antiandrogens for advanced prostate cancer confers survival benefits, although it remains controversial. Also, we and others have reported the effective...

Lewis, D., 1955: Sexual incompatibility. With the nongeneticist in mind the author gives a general account of the genetical and evolutionary aspects of incompatibility in the higher and lower plants.

Shih, C-Pang.; Lin, Y-Chun.; Chan, Y-Ying.; Hsu, K-Hung., 2015: Employing infectious disease physicians affects clinical and economic outcomes in regional hospitals: evidence from a population-based study. Infectious disease physicians (IDPs) play a major role in patient care, infectious disease control, and antibiotic use in hospitals. The aim of this research is to explore the effects of employment of IDPs on patients' prognosis and the relat...

Cabral, S.; Resende, R.A.; Clansey, A.C.; Deluzio, K.J.; Selbie, W.Scott.; Veloso, Aónio.P., 2015: A Global Gait Asymmetry Index. High levels of gait asymmetry are associated with many pathologies. Our long-term goal is to improve gait symmetry through real-time biofeedback of a symmetry index. Symmetry is often reported as a single metric or a collective signature of multip...

Montgomery-Andersen, R.A.; Borup, I., 2012: Family support and the child as health promoting agent in the Arctic - "the Inuit way". In the context of the UN's 1990 'Convention on the Right's of the Child' 1990, and the associated definition of health promotion as a community's ability to recognise, define and make decisions on how to create a healthy s...

Ommanney, F. D., 1932: The vascular network (Retia mirabilis) of the Fin Whale (Balaenoptera physalus). Discovery Reports Cambridge, 5: 327-362

Spencer, R. P., 1993: Life prolongation with dietary restriction: Protection of genome and core metabolism and the role of glycosylation. Life prolongation with dietary restriction can be found in much of the animal kingdom and thus is a phenomenon that is evolutionary conserved. We proposed that one benefit of this is protection of the genome at lower dietary intake, perhaps by red...