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Preparation of directly compressible powders of a physical mixture and a complex of theophylline pheno barbital using spray drying


, : Preparation of directly compressible powders of a physical mixture and a complex of theophylline pheno barbital using spray drying. International Journal of Pharmaceutics (Kidlington) 18(3): 335-344

A directly compressible powder of the physical mixture and the complex of theophylline and phenobarbital was prepared directly from droplets using a spray-drying technique. Aqueous or NH4OH slurries of theophylline and phenobarbital, with colloidal silica or methylcellulose, were atomized by a centrifugal wheel atomizer into a drying chamber held at various temperatures. The products prepared from the aqueous slurry were physical mixtures of theophylline and phenobarbital with a small amount of the molecular complex. From the NH4OH slurry, the molecular complex containing a small amount of theophylline or phenobarbital was prepared. The parameters affecting the amount of the molecular complex contained in the resultant products were the amounts of excipients, i.e. colloidal silica or methylcellulose, and the composition ratio of theophylline to phenobarbital in the formulation used for spray-drying. Drying temperature also affected the amount of the molecular complex in the products.

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