EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of fluorine 18 labeled 6 fluoro 9 benzyl purine and 2 fluoro 9 benzyl purine as a potential brain scanning agent


, : Preparation of fluorine 18 labeled 6 fluoro 9 benzyl purine and 2 fluoro 9 benzyl purine as a potential brain scanning agent. International Journal of Applied Radiation & Isotopes 33(8): 633-636

The preparations of [18F]-6-fluoro-9-benzylpurine(I) and [18F]-2-fluoro-9-benzylpurine are described. I was prepared by 2 methods: halogen exchange of 6-chloro-9-benzylpurine with Ag18F; and displacement of trimethylpurin-6-ylammonium chloride with K18F, followed by 9N benzylation. The latter labeling method was far superior, both in radiochemical yield and in specific activity. I was relatively stable in a Tris-HCl buffer (0.4 M pH 7.6) at 37.degree. C but was easily hydrolyzed in 1 N HCl. Biodistribution of I in mice demonstrated high uptake in the brain. I is a potential brain-scanning radiopharmaceutical for positron computed tomography.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006173130

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Grabowski A., 1973: The biomass organic matter contents and caloric values of macrophytes in the lakes of the szeszupa drainage area. Polskie Archiwum Hydrobiologii 20(2): 269-282

Wroblewski, T.; Cardoso, J.; Ratovohery, D.; Gagandeep, S.; Paul, G.; Cherruau, B.; Legendre, C.; Houssin, D., 1995: Spontaneous bacterial peritonitis in cirrhotic rats. Journal of Hepatology 23(SUPPL 1): 209

Yavruyan E.G.; Safaryan L.A., 1975: Finds of the broad eared free tailed bat tadarida teniotis new record in the territory of the armenian ssr ussr. Biologicheskii Zhurnal Armenii 28(7): 90-93

Rzhonsnitskaya M. A., 1986: Main problems of the Devonian stratigraphy of the Soviet Union. Sovetskaya Geologiya 1986(3): 53-65

Heins, Rd, 1979: Pointers on poinsettia production. American vegetable grower and greenhouse grower 27(11): 6-7

Carlsson, G., 1967: Environmental factors influencing blackfly populations. A detailed methodology for the collection of information about blackflies is given, which was developed for investigations mainly in the Hol-arctic regions but is basically applicable to other parts of the world. A brief survey of the population d...

Flynn George J., 1995: Interplanetary dust; changes in the Zodiacal Cloud. Nature (London) 376(6536): 114

Neppel P.S.; Dimarco N.M.; Beitz D.C.; Topel D.G., 1978: Conversion of alanine aspartate and lactate to glucose and to carbon di oxide in liver from stress susceptible and stress resistant pigs. Federation Proceedings 37(3): 267

Chicheng Xu, Carlos Torres-Verdín, 2013: Pore System Characterization and Petrophysical Rock Classification Using a Bimodal Gaussian Density Function. This paper introduces a bimodal Gaussian density function to characterize pore-size distributions in terms of incremental pore volume versus logarithmic pore-throat radius. An inverse problem is formulated and solved to reconstruct mercury injecti...

Perkins, A. E.; Surti, S.; Karp, J. S.; Muehllehner, G., 2003: Imaging performance of A-PET, a GSO small animal 3-D PET scanner. Journal of Nuclear Medicine 44(5 Supplement): 9P, May