EurekaMag.com logo
+ Site Statistics
References:
47,893,527
Abstracts:
28,296,643
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of fluorine 18 labelled n fluoropyridinium triflate


, : Preparation of fluorine 18 labelled n fluoropyridinium triflate. Journal of Labelled Compounds & Radiopharmaceuticals 35(9): 999-1006

N-Fluoropyridinium triflate was labelled with 18F proceeding through N-trimethylsilylpyridinium triflate and [18F]F2 diluted to 1% in Ne. A typical experiment afforded this new fluorine-18 transfer reagent with up to 46% radiochemical yield. The specific activity of 18F-labeled N-fluoropyridinium triflate was determined by iodometric titration to be in the range of 4 .cntdot. 10-8 mg/Bq (1.5 mg/mCi; 1.67 .cntdot. 10-4 Ci/.mu.M).


Accession: 006173131

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Johnstrom, P.; Stone Elander, S., 1994: Synthesis of fluorine-18 labelled 2,2,2-trifluoroethyl triflate. Journal of Labelled Compounds & Radiopharmaceuticals 35(0): 146-147

Naruta Y.; Tani F.; Maruyama K., 1992: Meso perfluorination of porphyrins with n fluoropyridinium triflate. Octaethylporphyrin was perfluorinated at its meso-positions with N-fluoropyridinium triflate in 67% of a total yield.

Umemoto T.; Kawada K.; Tomita K., 1986: N fluoropyridinium triflate and its derivatives useful fluorinating agents. Tetrahedron Letters 27(37): 4465-4468

Kiesewetter D.O.; Finn R.D., 1989: Fluorine 18 fluoroethyl triflate preparation and reactions with amines. Journal of Labelled Compounds & Radiopharmaceuticals 26: 14-16

Oberdorfer F.; Hofmann E.; Maier Borst W., 1988: Preparation of a new fluorine 18 labelled precursor 1 fluorine 18 fluoro 2 pyridone. The new 18F-labelled precursor l-[18-F]fluoro-2-pyridone was prepared by reacting [18F]F2 with 2-(trimethylsiloxy)pyridine. This compound has potential as an easy to use yet selective labelling reagent in preparations, where fluorine carrier may b...

Anonymous, 1987: The first direct introduction of fluorine into the 2 up arabino configuration of purine nucleoside the synthesis of 2 fluoro 2 deoxyinosine via the 2 triflate derivative and of the 2 keto 3 deoxyinosine by elimination of the 3 triflate function

Horsch, A.K.; Hudson, K.; Goulding, R.W.; Day, A.J., 1977: The preparation of fluorine-18 labelled radiopharmaceuticals. International Journal of Applied Radiation and Isotopes 28(1-2): 53-65

Goulding, R.W.; Palmer, A.J., 1972: The preparation of fluorine-18 labelled p-fluorophenylalanine for clinical use. International Journal of Applied Radiation and Isotopes 23(3): 133-137

Kamarainen, E.L.isa; Kyllonen, T.; Nihtila, O.; Bjork, H.; Solin, O., 2004: Preparation of fluorine-18-labelled fluoromisonidazole using two different synthesis methods. 18F-labelled fluoromisonidazole (1H-1-(3-(18F)fluoro-2-hydroxypropyl)-2-nitroimidazole; ((18F)FMISO)) is used as an in vivo marker of hypoxic cells in tumours and ischaemic areas of the heart and the brain. The compound plays an important role in...

Oberdorfer F.; Hofmann E.; Maier Borst W., 1989: Preparation of fluorine 18 labelled 5 fluorouracil of very high purity. 5-[18F]Fluorouracil was prepared by direct fluorination of uracil in acetic acid using [18F]F2 diluted in neon. The labelled product was obtained with a purity of .gtoreq. 99% following preparative HPLC. Quality control consisted of two different...