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Preparation of granules by fluidized bed granulator with turning flow


Yakuzaigaku 48(1): 41-47
Preparation of granules by fluidized bed granulator with turning flow
A new device, which is a turning flow fluidized-bed granulator, was produced by way of experiment. The base of this device is a normal fluidized-bed granulator (FLO-5). It has a special slit for leading to turning air flow, its fluidized-bed tower is a cornic type at upper side and is a bellows type at lower side. Granules of cornstarch-lactose were prepared with this device. The following view was shown from the results. Compared with granules prepared with normal fluidized-bed granulator, granules prepared with this device were characteristics of narrow particle size distribution, high apparent density, and high sphericity. Differences between both granules are caused by rolling motion on fluidized-bed wall and centrifugal force by turning air flow. On account of these improvements of flowability of granules, those became to be handled were easily. The granulating rate of this device was higher than that of the normal type. It shows that binder solution drops were used for granulation at higher availability than the normal type.


Accession: 006173186



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