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Preparation of harringtonine from cephalotaxine

Journal of Organic Chemistry 44(1): 63-67
Preparation of harringtonine from cephalotaxine
Use of a racemic compound as a side-chain synthon provides a 3-step conversion of l-cephalotaxine into a readily separable, .apprx. 1:1 mixture of the clinically useful anticancer drug harringtonine and its side-chain epimer. The synthesis of the racemic compound is described.

Accession: 006173196

DOI: 10.1021/jo01315a015

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