+ Site Statistics
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of harringtonine from cephalotaxine

, : Preparation of harringtonine from cephalotaxine. Journal of Organic Chemistry 44(1): 63-67

Use of a racemic compound as a side-chain synthon provides a 3-step conversion of l-cephalotaxine into a readily separable, .apprx. 1:1 mixture of the clinically useful anticancer drug harringtonine and its side-chain epimer. The synthesis of the racemic compound is described.

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006173196

DOI: 10.1021/jo01315a015

PDF Full Text: Preparation of harringtonine from cephalotaxine

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Patra, M.; Mitra, M.; Chakrabarti, A.; Mukhopadhyay, C., 2014: Binding of polarity-sensitive hydrophobic ligands to erythroid and nonerythroid spectrin: fluorescence and molecular modeling studies. We have used three polarity-sensitive fluorescence probes, 6-propionyl 2-(N,N-dimethyl-amino) naphthalene (Prodan), pyrene and 8-anilino 1-naphthalene sulphonic acid, to study their binding with erythroid and nonerythroid spectrin, using fluoresce...

Anonymous, 1961: Autopsy on a Murder Trial. Canadian Medical Association Journal 85(4): 205-206

Nadjafi, A.S., 1977: Total gastrectomy with substitute stomach. A modified technique of jejunum-reservoir after total gastrectomie for gastric cancer is recommended. The advantages of this method are the simplicity of technique, the preservation of duodenal passage, the avoiding of reflux and the normal emptyi...

Li ChunYang, 2000: Population differences in water-use efficiency of Eucalyptus microtheca seedlings under different watering regimes. Gas exchange, water-use efficiency (WUE), carbon isotope composition ( delta 13C) and growth traits were compared among 5 populations of Eucalyptus microtheca. Seedlings grown from seed collected across the natural distribution of the species were...

Maciel, L.M.; Lima-Filho, E.C.; Moreira, A.C., 1985: Quantitative analysis of ultradian luteinizing hormone secretion in normal men. Basal pulsatile secretion of luteinizing hormone (LH) was studied in 8 healthy adult men and analyzed by mathematical and statistical techniques. LH pulses previously defined by semiquantitative criteria resisted the data-smoothing techniques empl...

Katschnig, H.; Nutzinger, D.O., 1990: Panic attacks and panic syndrome--diagnosis and therapy. Paroxysmal states of anxiety that cannot be traced back to somatic causes have been called panic attacks since the publication of the Diagnostic and Statistical Manual of Mental Disorders (DSM III) of the American Psychiatric Association. This ter...

Fowst, G., 1971: Deontology of the researchers concerning drug information for the physician. Bollettino Chimico Farmaceutico 110(10): 560-564

Cooper, B.R.; Breese, G.R.; Howard, J.L.; Grant, L.D., 1972: Enhanced behavioral depressant effects of reserpine and -methyltyrosine after 6-hydroxydopamine treatment. Psychopharmacologia 27(2): 99-110

Seward, J. P., 1941: The hormonal induction of behavior. The tendency of modern psychology to emphasize peripheral rather than central mechanisms, because of their greater ease of objective approach, has led to a theory that, in reproductive activities, the hormones exert their effects on behavior throu...

Fried P.M.; Meister E., 1987: Inheritance of leaf and head resistance of winter wheat to septoria nodorum in a diallel cross. A diallel analysis of four parents of similar heading date and plant height but differing in resistance to Septoria nodorum on leaves and heads (as estimated by area under the disease progress curves) showed that the genetic variation is mainly ad...