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Preparation of highly immunogenic protein conjugates by direct coupling to glutaraldehyde treated cells comparison with commonly used preparations



Preparation of highly immunogenic protein conjugates by direct coupling to glutaraldehyde treated cells comparison with commonly used preparations



Journal of Immunological Methods 40(2): 209-218



A simple and rapid method of preparing highly immunogenic protein samples by use of glutaraldehyde for direct coupling to cells is described. The usefulness of the technique is illustrated in 2 model preparations [in rabbits and mice] based on detoxification [antitoxin production] with tetanus toxin coupling to L1210 leukemia cells or to lymphocytes.

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Accession: 006173227

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PMID: 6166687



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