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Preparation of iodine 125 labeled n pyrazole methylene tetracycline and study of its behavior in the body of intact and tumor bearing animals


, : Preparation of iodine 125 labeled n pyrazole methylene tetracycline and study of its behavior in the body of intact and tumor bearing animals. Khimiko-Farmatsevticheskii Zhurnal 13(7): 16-20

Preparation of iodine-125 labeled N-C4-pyrazole-methylene-tetracycline and study of its behavior in the body of intact and tumor-bearing animals. N-C4-125I-pyrazole-methylene-tetracycline was synthesized from 125I-pyrazole and tetracycline. Study of the behavior of the obtained preparation in intact and tumor-bearing rats, including data of external radiometry of control and tumor tissue, showed that the maximal level of incorporation of the preparation in the tumor was noted 24 h after administration. The ratio of the specific activity of the portion of the tissue affected by the tumor growth process to that of unaffected tissue was 6 according to data of radiometry bioprobe 24 h after administration, and 5.52 according to data of external radiometry. This preparation may be used for detection of malignant tumors by external radiometry.

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