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Preparation of iso propyl retinoate and ethyl retinoate


, : Preparation of iso propyl retinoate and ethyl retinoate. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 15(7): 665-666

Isopropyl retinoate is used for the treatment of human skin disorders (acne, seborrhea, pruritis, etc.). A simple method for the preparation of isopropyl retinoate and ethyl retinoate from retinol in high yields was reported. The method involved oxidation of retinol by a mixture of NaCN, AcOH and MnO2 to give retinoic acid which was esterified in situ by ethanol or propanol used as a solvent.

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