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Preparation of iso propyl retinoate and ethyl retinoate

, : Preparation of iso propyl retinoate and ethyl retinoate. Indian Journal of Chemistry Section B Organic Chemistry Including Medicinal Chemistry 15(7): 665-666

Isopropyl retinoate is used for the treatment of human skin disorders (acne, seborrhea, pruritis, etc.). A simple method for the preparation of isopropyl retinoate and ethyl retinoate from retinol in high yields was reported. The method involved oxidation of retinol by a mixture of NaCN, AcOH and MnO2 to give retinoic acid which was esterified in situ by ethanol or propanol used as a solvent.

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Related references

Miller D.A.; Deluca H.F., 1985: Formation of ethyl retinoate and its dependence upon coenzyme. Federation Proceedings 44(3): 545

Miller, D.A.; DeLuca, H.F., 1985: Activation of retinoic acid by coenzyme A for the formation of ethyl retinoate. All-trans-retinoic acid is metabolized to a less polar metabolite in rat liver microsomes. This metabolite was proven to be ethyl retinoate by cochromatography on high-performance liquid chromatography, base hydrolysis to all-trans-retinoic acid,...

Morgan, B.; Thompson, J.N., 1966: The preparation and biological activity of methyl 5,6-epoxy-retinoate. 1. Oxidation of methyl retinoate with monoperphthalic acid gave methyl 5,6-epoxyretinoate, obtained as pale-yellow crystals, m.p. 89 degrees . 2. The structure of the epoxide was confirmed by its ultraviolet, infrared, nuclear-magnetic-resonance a...

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