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Preparation of magnetic gelatin microspheres for the targeting of drugs

Archives of Pharmacal Research (Seoul) 9(3): 145-152

Preparation of magnetic gelatin microspheres for the targeting of drugs

Magnetically responsive gelatin microspheres for the targeting of drugs have been prepared using a water-in-oil emulsion technique with chemical cross-linking of the protein. The manufacturing variables affecting microsphere size, size distribution and surface characteristics have been examined as well as the magnetic responsiveness in vitro. Seasame oil was utilized for non-aqueous phase and magnetic gelatin microspheres of different size from 1.89 to 14.88 .mu.m in mean diamter could be obtained with variation of HLB values of non-ionic surfactants. The content of magnetite which uniformly distributed throughout the microspheres was 26.7% (w/w). It was possible to control the localization of magnetic gelatin microspheres at specific sites within capillary models by using external magnetic field of under 5K gauss.

Accession: 006173443

DOI: 10.1007/bf02899998

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