EurekaMag.com logo
+ Translate

Preparation of magnetic gelatin microspheres for the targeting of drugs


, : Preparation of magnetic gelatin microspheres for the targeting of drugs. Archives of Pharmacal Research (Seoul) 9(3): 145-152

Magnetically responsive gelatin microspheres for the targeting of drugs have been prepared using a water-in-oil emulsion technique with chemical cross-linking of the protein. The manufacturing variables affecting microsphere size, size distribution and surface characteristics have been examined as well as the magnetic responsiveness in vitro. Seasame oil was utilized for non-aqueous phase and magnetic gelatin microspheres of different size from 1.89 to 14.88 .mu.m in mean diamter could be obtained with variation of HLB values of non-ionic surfactants. The content of magnetite which uniformly distributed throughout the microspheres was 26.7% (w/w). It was possible to control the localization of magnetic gelatin microspheres at specific sites within capillary models by using external magnetic field of under 5K gauss.

Accession: 006173443

DOI: 10.1007/bf02899998

Download PDF Full Text: Preparation of magnetic gelatin microspheres for the targeting of drugs


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Cao, F-Liang.; Xi, Y-Wei.; Tang, L.; Yu, A-Hua.; Zhai, G-Xi., 2009: Preparation and characterization of curcumin loaded gelatin microspheres for lung targeting. To study the preparation technology and physicochemical characterization of curcumin loaded gelatin microspheres for lung targeting. Curcumin loaded gelatin microspheres for lung targeting were prepared by the emulsion crosslinking method, and the...

Hao, Z.; Qu, B.; Wang, Y.; Tang, S.; Wang, G.; Qiu, M.; Zhang, R.; Liu, Y.; Xiao, X., 2012: Preparation and characterization of lung-targeting ceftiofur-loaded gelatin microspheres. Ceftiofur is an effective antibiotic against respiratory infections in livestock. However, ceftiofur concentration that is found in lungs after intravenous injection is not effective. Fortunately, ceftiofur-loaded gelatin microsphere (Cef-MS) enjo...

Wu, C.B.n; He, S.M.i; Gao, W.W.i; Wei, S.L., 1994: Preparation and characters of adriamycin magnetic gelatin microspheres. The magnetic gelatin microsphere (MG-ms) used in arterial embolization was prepared by emulsion-crosslinking method. The microspheres were digested with HCl-HNO-3 (4:1) mixture, and the alpha-Fe-2O-3 in MG-ms can be accurately determined by atomic...

Lee K.C.; Koh I.B., 1987: Intravascular tumor targeting of aclarubicin loaded gelatin microspheres preparation biocompatibility and biodegradability. This study is to evaluate the potential use of aclarubicin-loaded gelatin microspheres as an intravascular biodegradable drug delivery system for the regional cancer therapy. The diameter of the microspheres prepared by water in oil emulsion polym...

Schröder, U.; Mosbach, K., 1982: Magnetic microspheres for targeting of drugs. Magnetic microspheres were prepared from starch. The microspheres could be crosslinked with various agents, and drugs could be entrapped adsorbed, or covalently coupled to the microspheres.

Widder, K.J.; Senyei, A.E., 1983: Magnetic microspheres: a vehicle for selective targeting of drugs. Pharmacology & Therapeutics 20(3): 377-395

Narayani, R.; Rao, K.P.nduranga, 1993: Preparation, characterisation and in vitro stability of hydrophilic gelatin microspheres using a gelatin-methotrexate conjugate. The anticancer drug methotrexate (MTX) was covalently linked to gelatin using carbodiimide as the coupling agent. The resulting gelatin-methotrexate conjugate (GMC) was separated by gel filtration and characterized by UV and IR spectroscopy. The d...

Kang, J.C.; Wei, S.L., 1997: Study of magnetic microspheres for purging cancer cells from bone marrow. II. Preparation of polystyrene magnetic microspheres.. Magnetic microspheres (MS) used to purge tumor cells from human bone marrow were prepared with a two step method. Main factors that can influence the magnetization result were discussed. The MS were coated with polyacrolein which has active aldehy...

Kang, J.C.; Wei, S.L., 1997: Study on magnetic microspheres for purging cancer cells from bone marrow: II. Preparation of polystyrene magnetic microspheres. Magnetic microspheres(MS) used to purge tumor cells from human bone marrow were prepared with a two step method. Main factors that can influence the magnetization result were discussed. The MS were coated with polyacrolein which has active aldehyd...

Suzuki, T.; Sato, E.; Matsuda, Y.; Tada, H.; Unno, K.; Kato, T., 1989: Preparation of zein microspheres conjugated with antitumor drugs available for selective cancer chemotherapy and development of a simple colorimetric determination of drugs in microspheres. Zein microspheres conjugated with antitumor drugs (mitomycinc (MMC), daunomycin hydrochloride (DM), peplomycin sulfate (PEP)) were prepared by using a dimethyl sulfoxide (DMSO)-H2O system. MMC with low solubility in H2O was easily entrapped by the...