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Preparation of mouse anti serum against isologous aggregated immuno globulins and investigation of its effect on rosette forming cells






Byulleten' Eksperimental'noi Biologii i Meditsiny 84(12): 698-700

Preparation of mouse anti serum against isologous aggregated immuno globulins and investigation of its effect on rosette forming cells

A method of obtaining antisera against isologous aggregated mouse immunoglobulins [MAAS] was described. MAAS blocked the in vitro antigen-binding receptors of the immune rosette-forming cells. MAAS was injected to mice immunized with SRBC [sheep red blood cells]. In comparison with the immunized mice given normal isologous serum, rosette-forming B[bone marrow-derived]-cells were absent in the spleen of mice given MAAS at the peak of isologous response. The antibody-forming cell count was not decreased under the influence of MAAS.

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Accession: 006173533



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