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Preparation of mouse anti serum against isologous aggregated immuno globulins and investigation of its effect on rosette forming cells



Preparation of mouse anti serum against isologous aggregated immuno globulins and investigation of its effect on rosette forming cells



Byulleten' Eksperimental'noi Biologii i Meditsiny 84(12): 698-700



A method of obtaining antisera against isologous aggregated mouse immunoglobulins [MAAS] was described. MAAS blocked the in vitro antigen-binding receptors of the immune rosette-forming cells. MAAS was injected to mice immunized with SRBC [sheep red blood cells]. In comparison with the immunized mice given normal isologous serum, rosette-forming B[bone marrow-derived]-cells were absent in the spleen of mice given MAAS at the peak of isologous response. The antibody-forming cell count was not decreased under the influence of MAAS.

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Accession: 006173533

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