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Preparation of n amino n' tert butoxycarbonyl l proline esters and attempted cyclization into 1 oxa 4 5 diazepin 2 ones






Acta Pharmaceutica Jugoslavica 30(4): 183-188

Preparation of n amino n' tert butoxycarbonyl l proline esters and attempted cyclization into 1 oxa 4 5 diazepin 2 ones

A new N-amino-proline derivative, N-amino-(N'-tert-butoxy-carbonyl)-L-proline was prepared in .apprx. 60% yield. It was alkylated with .alpha.-halomethyl-aryl ketones to give benzoyl methyl esters 2-5. Attempts to obtain ring closure of hydrobromides (prepared by deprotection of 2-5 with 2.5% hydrobromic acid in acetic acid) into 1-oxa-4,5-diazepin-2-ones failed.

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Accession: 006173551



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