+ Translate

Preparation of new 4 4' linked bisacridines 9 9' linked bisacridines and 4 4' 9 9' bi linked bisacridines

, : Preparation of new 4 4' linked bisacridines 9 9' linked bisacridines and 4 4' 9 9' bi linked bisacridines. Heterocycles (Tokyo) 24(5): 1419-1428

New bis-derivatives belonging to the acridine series have been prepared. These compounds are bis(4-amino-9-acridanones) and bis(4-amino-9-thioacridanones) linked in positions 4,4' or 9,9'. There are also some 4,4'-diaminoacyl-9,9'-dithioalkyl bi-linked bis-acridines. In any case, chemical structures are discussed with reference to the 13C NMR chemical shifts, as well as to the HSAB concept.

(PDF 0-2 workdays service)

Accession: 006173571

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Related references

Lorente, A.; Vázquez, Y.G.; Fernández, Mía-José.; Ferrández, A., 2004: Bisacridines with aromatic linking chains. Synthesis, DNA interaction, and antitumor activity. Synthesis of a series of bisacridine derivatives containing rigid aromatic linking chains is described. Their DNA interaction and in vitro cytotoxicity against HT-29 human carcinoma cells are reported.

Assa-Munt, N.; Leupin, W.; Denny, W.A.; Kearns, D.R., 1985: Proton nmr study of the binding of bisacridines to deoxy at 5 deoxy at 5 2. dynamic aspects. Measurments of the 1H NMR spectra and relaxation ratyes were used to study the dynamic properties of 9-aminoacridine (9AA) and 4 bis(acridine) complexes with d(AT)5-d(AT)5. The behavior of the 9AA (monointercalator) and that of C8 (bisintercalator...

Assa-Munt, N.; Denny, W.A.; Leupin, W.; Kearns, D.R., 1985: Proton nmr study of the binding of bisacridines to deoxy at 5 deoxy at 5 1. mode of binding. 1H NMR was used to investigate the mode of binding to d(AT)5-d(AT)5 of a series of bis(acridine) derivatives connected by different types of linker chains. The length and character (ionic, aliphatic, rigids and flexible) of the linker chains have...

Mannani R.; Atassi G.; Galy A.M.; Galy J.P.; Barbe J., 1991: Preparation of 3 3 linked bisacridinones 9 9 linked bisthioacridines and 3 3 9 9 bi linked bisthioacridinones. European Journal of Medicinal Chemistry 26(1): 117-119

Hoffmann, R.; Leeflang, B.; Barse, M.-De; Kamerling, J.; Vliegenthart, J., 1991: Characterisation by 1H-n.m.r. spectroscopy of oligosaccharides, derived from arabinoxylans of white endosperm of wheat, that contain the elements linked to 4 -beta-D-Xylp-(1 linked to or linked to 4)-beta-D-Xylp-1 linked to. The structure of penta- to hepta-saccharides, generated by digestion of purified wheat-endosperm arabinoxylan with endo-(1 linked to 4)-beta-D-xylanase and isolated by gel-permeation chromatography on Bio-Gel P-6 followed by high-performance anion...

Goto, F.O.awa, T., 1992: Synthesis of a sulfated glycopeptide corresponding to the carbohydrate-protein linkage region of proteoglycans: beta-D-GlcA-(1 linked to 3)-beta-D-Gal-(1 linked to 3)-beta-D-Gal-(1 linked to 4)-beta-D-Xyl-(1 linked to 3)-Ser. A sulfated glycotetraosyl serin 4 was synthesized in a stereocontrolled manner by employing a key glycotetraosyl donor 7 and a serine derivative 6.

Meyer, R.A., 1985: X-linked hypophosphatemia (familial or sex-linked vitamin-D-resistant rickets). X-linked hypophosphatemic (Hyp) mice. American Journal of Pathology 118(2): 340-342

Kato, M.; Peng, Y.; Kretzschmar, E.; Chen, P.; Raca, G.; Kitamura, K.; Sugiyama, N.; Fukuda, T.; Morohashi, K.; Das, S.; Dobyns, W.B., 2002: Genotype-phenotype analysis in patients with X-linked lissencephaly with abnormal genitalia , X-linked infantile spasms and X-linked mental retardation. American Journal of Human Genetics 71(4 Supplement): 179, October

Kingsley, D.M.; Kozarsky, K.F.; Segal, M.; Krieger, M., 1986: Three types of low density lipoprotein receptor-deficient mutant have pleiotropic defects in the synthesis of N-linked, O-linked, and lipid-linked carbohydrate chains. Biochemical, immunological, and genetic techniques were used to investigate the genetic defects in three types of low density lipoprotein (LDL) receptor-deficient hamster cells. The previously isolated ldlB, ldlC, and ldlD mutants all synthesized...

McManus, F.P.; Khaira, A.; Noronha, A.M.; Wilds, C.J., 2013: Preparation of covalently linked complexes between DNA and O(6)-alkylguanine-DNA alkyltransferase using interstrand cross-linked DNA. O(6)-alkylguanine-DNA alkyltransferases (AGT) are responsible for the removal of alkylation at both the O(6) atom of guanine and O(4) atom of thymine. AGT homologues show vast substrate differences with respect to the size of the adduct and which...