EurekaMag.com logo
+ Translate

Preparation of novel, curable capillary gas chromatographic systems and their application to the analysis of underivatized barbiturates and other controlled drugs of forensic interest


, : Preparation of novel, curable capillary gas chromatographic systems and their application to the analysis of underivatized barbiturates and other controlled drugs of forensic interest. Journal of Chromatography 354: 219-229

Three novel stationary phases have been prepared for the analysis of underivatised barbiturates by incorporating different monomers. N,N'-di(but-3-enyl)amylobarbital, N,N'-di(pent-4-enyl)amylobarbital and N,N'-di(hex-5-enyl)amylobarbital into a standard SE-54 matrix. The chromatographic behaviour of these columns is compared with a standard immobilised SE-54 column. They are shown to be less polar than the previously reported N,N'-diallylamylobarbital incorporated column. Of the three new phases, the one incorporating the monomer N,N'-di(but-3-enyl)-amylobarbital shows the best performance for the separation of a mixture containing 22 barbiturates but all are selective, very efficient, inert and can be used up to at least 300.degree. C. The versatility of these new phases is demonstrated further by the analysis of other drugs of abuse. They offer unique selectivities not previously available.

(PDF 0-2 workdays service)

Accession: 006173590

PMID: 2871036

Submit PDF Full Text: Here


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Related references

Chow W.M.L.; Caddy B., 1985: Improved method for the preparation of immobilized pyrimidone silicones as polar stationary phases used for the capillary column gas chromatographic separation of underivatized barbiturates. The preparation and chromatographic performance of SE-54 columns into which 2-100% (wt/wt) of a pyrimidone moiety were incorporated are described. The resulting pyrimidonesilicones were rendered non-extractable by treatment with peroxide. Best per...

Plotczyk L.L., 1982: Application of fused silica capillary gas chromatography to the analysis of underivatized drugs. The feasibility of using fused-silica capillary chromatography for the routine analysis of several common drugs is illustrated. Considerations for optimizing on-column and splitless injection are discussed as part of a study of system discriminati...

Williams, T.A.; Riddle, M.; Morgan, S.L.; Brewer, W.E., 1999: Rapid gas chromatographic analysis of drugs of forensic interest. High-speed gas chromatographic (GC) screening for drugs of forensic relevance is performed using a commercial Flash(R) GC instrument in which the chromatographic column is resistively heated at rates of up to 30degreeC/s. Temperature programming c...

Ferslew, K.E.; Hagardorn, A.N.; McCormick, W.F., 1995: Application of micellar electrokinetic capillary chromatography to forensic analysis of barbiturates in biological fluids. Micellar electrokinetic capillary chromatography (MECC) is a form of capillary zone electrophoresis. Addition of a surfactant produces micelles in an aqueous/organic buffer. Separation of drugs is obtained via differences in the electrophoretic mo...

Chow W.M.L.; Caddy B., 1985: Separation of underivatized barbiturates by capillary column gas chromatography preparation of medium polar polymethylsiloxane columns to optimize selectivity. Methods for the preparation of immobilized non-polar polymethylsiloxane caillary columns are described, for the analysis of underivatized barbiturates. The columns produced can resolve most of the common underivatized barbiturates, but lack the se...

Street, H.V.; Vycudilik, W.; Machata, G., 1979: Gas-liquid chromatography of submicrogram amounts of drugs. V. Preparation of low-activity packed columns and their application to the toxicological analysis of underivatized polar drugs in the low nanogram range. When diatomaceous earth and glass columns are acylated prior to coating with a silicone liquid phase, then subjected to heat treatment in an atmosphere of nitrogen, gas chromatographic columns can be prepared that show a marked reduction in adsorp...

Street H.V.; Vycudilik W.; Machata G., 1979: Gas liquid chromatography of submicrogram amounts of drugs part 5 preparation of low activity packed columns and their application to the toxicological analysis of underivatized polar drugs in the low nanogram range. When diatomaceous earth and glass columns were acylated prior to coating with a silicone liquid phase, then subjected to heat treatment in an N2 atmosphere, gas chromatographic columns were prepared that showed a marked reduction in adsorption. Th...

Lurie I.S., 1981: Improved isocratic mobile phases for the reverse phase ion pair chromatographic analysis of drugs of forensic interest. Most drug exhibits of forensic interest can be analyzed by reverse phase ion-pair chromatography using a Microbondapak-C-18 column with 2 isocratic mobile phases. These systems employing methanesulfonic acid represent a great improvement in resolu...

Gottardo, R.; Mikšík, I.; Aturki, Z.; Sorio, D.; Seri, C.; Fanali, S.; Tagliaro, F., 2012: Analysis of drugs of forensic interest with capillary zone electrophoresis/time-of-flight mass spectrometry based on the use of non-volatile buffers. The present work is aimed at investigating the influence of the background electrolyte composition and concentration on the separation efficiency and resolution and mass spectrometric detection of illicit drugs in a capillary zone electrophoresis-...

Mackay G.A.; Reed G.D., 1991: The application of capillary sfc packed column sfc and capillary sfc ms in the analysis of controlled drugs. Multi-component mixtures of controlled drugs, drug impurities, and adulterants have been analyzed by capillary SFC-FID, packed column SFC-UV, and capillary SFC-MS. Isocratic packed column SFC has been performed with binary and ternary mobile phase...