+ Site Statistics
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of phenylbutazone polymorphs and their transformation in solution

Preparation of phenylbutazone polymorphs and their transformation in solution

Chemical & Pharmaceutical Bulletin (Tokyo) 36(3): 1063-1073

Polymorphism of phenylbutazone was investigated in detail. Pure .alpha. form of phenylbutazone could not be obtained by conventional methods, but it was found that the .beta. form was transformed to the stable .alpha. form in ethanol solution at At 15 and, the .beta. form was transformed to a mixture of the .alpha. and .delta. forms, while at, the .alpha. form in the mixture was converted to the .delta. form. These results showed that the preparation of a pure polymorphic form by means of recrystallization in solution is not necessarily straightforward. The dissolution behavior of each form in buffer solution was examined next. The transition temperatures of the pairs of .alpha. and .delta. forms and of .alpha. and .beta. forms were 29.0 and, respectively, in buffer solution as determined by means of the non Linear van't Hoff model proposed by Grant et al. The heats of fusion of the .alpha., .beta. and .delta. forms were 8.74, 6.48 and 6.85 kcal/mol, and their melting points were 91.2, 93.3 and, respectively. These results suggested that the pair of .beta. and .delta. forms is in a monotropic relation and the pairs of .alpha. and .beta. forms and of .alpha. and .delta. forms are in enantiotropic relationships.

(PDF same-day service: $19.90)

Accession: 006173661

Download citation: RISBibTeXText

DOI: 10.1248/cpb.36.1063

Related references

Preparation and transformation of true nifedipine polymorphs: investigated with differential scanning calorimetry and X-Ray diffraction pattern fitting methods. Journal of Pharmaceutical Sciences 100(5): 1944-1957, 2011

Solid-state versus solution preparation of two crystal forms of [HN(CH2CH2)3NH][OOC(CH2)COOH]2. Polymorphs or hydrogen bond isomers?. Chemical Communications: 976-977, 2004

Dissolution behavior of phenylbutazone polymorphs. Yakugaku Zasshi 107(12): 1005-1007, 1987

Physicochemical characterization of spray-dried phenylbutazone polymorphs. Journal of Pharmaceutical Sciences 73(2): 173-179, 1984

Phenylbutazone in certain allergic phenomena. I. Phenylbutazone in anaphylactic shock. II. Phenylbutazone in histamine shock. III. Phenylbutazone in the Sanarelli-Shwartzman pheno-menon. G. Batt. Immun, 48: 134-148; 149-156; 157-163, 1955

Contribution to the study on phenylbutazone-sulfamides. I. -- Phenylbutazone-sulfanilamide and phenylbutazone-sulfathiazol associations. Annales Pharmaceutiques Francaises 37(5-6): 175-180, 1979

One-step preparation of competent Escherichia coli: transformation and storage of bacterial cells in the same solution. Proceedings of the National Academy of Sciences of the United States of America 86(7): 2172-2175, 1989

Transformation kinetics & metastabilities of Mg (sub 2) SiO (sub 4) polymorphs. Eos, Transactions, American Geophysical Union 74(16, Suppl, 1993

Pharmaceutical and pharmacological evaluation of Burow's solution (aluminum acetate solution), hospital preparation, and development of its rapid preparation method. Yakugaku Zasshi 124(11): 833-840, 2004

The polymorphs of CaCO (sub 3) and the aragonite-calcite transformation. Reviews in Mineralogy 11: 191-225, 1983

Phase transformation in conformational polymorphs of nimesulide. Journal of Pharmaceutical Sciences 100(6): 2287-2299, 2011

Preparation of lipids labeled with tritium by heterogeneous catalytic isotope exchange with gaseous tritium in solution 2 preparation of tritium labeled arachidonic acid and its transformation into prostaglandin e 2 and prostaglandin b 2. 1979

Preparation of hydrophilic poly(lactic acid) tissue engineering scaffold via (PLA)-(PLA-b-PEG)-(PEG) solution casting and thermal-induced surface structural transformation. Journal of Biomaterials Science. Polymer Edition 26(17): 1286-1296, 2016