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Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization


, : Preparation of Rocky Mountain spotted fever vaccine suitable for human immunization. Journal of Clinical Microbiology 1(6): 500-503

Rocky Mountain spotted fever vaccine was produced from rickettsiae grown in chicken embryo cells in roller bottle cultures. The rickettsiae were concentrated and purified by passage through a sucrose gradient and inactivated with formalin. This vaccine satisfactorily passed preinactivation and final container testing and is believed to be superior to the presently available yolk sac vaccine.


Accession: 006173829

PMID: 809483

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Related references

State Health Dep (Viral Rickettsial Zoonoses Br), 1990: Rocky mountain spotted fever and human ehrlichiosis usa 1989 rocky mountain spotted fever. Archives of Dermatology 126(7): 858-859

Magnarelli, LA.; Anderson, JF.; Burgdorfer, W., 1979: Rocky Mountain spotted fever in Connecticut: human cases, spotted fever group rickettsiae in ticks, and antibodies in mammals. Three parameters were used in 1976 and 1977 to assess the status of Rocky Mountain spotted fever (RMSF) in Connecticut USA: compilation and review of clinical data on suspected human cases for 13 yr (1965-1977), examination of tick tissues for spo...

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Sexton, D.J.; Burgdorfer, W.; Thomas, L.; Norment, B.R., 1976: Rocky Mountain spotted fever in Mississippi: survey for spotted fever antibodies in dogs and for spotted fever group rickettsiae in dog ticks. During epidemiological studies of Rocky Mountain spotted fever caused by Rickettsia rickettsi in Mississippi in 1973, dogs were surveyed for antibodies to spotted fever group antigens and for ticks infected with rickettsiae of the spotted fever gr...

Sexton, D.J.; Burgdorfer, W.; Thomas, L.; Norment, B.R., 1976: Rocky Mountain spotted fever in Mississippi: survey for spotted fever antibodies in dogs and for spotted fever group reckettsiae in dog ticks. During epidemiologic studies of Rocky Mountain Spotted Fever in Mississippi in 1973, dogs were surveyed for antibodies tp spotted fever group antigens and for tick parasites infected with rickettsiae of the spotted fever group. Fifty-three (46%) o...

Maugh, T.H., 1978: Rickettsiae: a new vaccine for Rocky Mountain spotted fever. A new method (developed by Kenyon et al.) for preparing Rocky Mountain Spotted Fever (RMSV) vaccine was described which increased the number of rickettsiae obtained from cultures and eliminated the egg yolk lipids and proteins. The vaccine, prepar...

Walker, D.H.; Montenegro, M.R.; Hegarty, B.C.; Tringali, G.R., 1984: Rocky Mountain spotted fever vaccine: a regional need. Because the killed Rickettsia vaccines have failed to provide protection against Rocky Mountain spotted fever, we approached the problem of protective immunity to Rickettsia rickettsii with a closely related, live, less pathogenic spotted fever Ri...

Shepard, C.C., 2011: Vaccine prophylaxis of Rocky Mountain spotted fever. New York State Journal of Medicine 47(14): 1589-1589

Vishwanath, S.; McDonald, G.A.; Watkins, N.G., 1990: A recombinant Rickettsia conorii vaccine protects guinea pigs from experimental boutonneuse fever and Rocky Mountain spotted fever. There are no vaccines against boutonneuse fever and Rocky Mountain spotted fever. Previous studies have identified a Rickettsia rickettsii surface protein as a vaccine candidate and shown that an antigenically related protein is present in R. cono...