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Preparation of Salganicoff's platelet strip

Zhongguo Yao Li Xue Bao 7(3): 247-251
Preparation of Salganicoff's platelet strip
Salganicoff's platelet strip, a new biological preparation, is used to observe the behavior of the platelet contractible protein with isometric tension. By centrifuge the platelets were deposited on a flat surface of a highly compliant nylon mesh. With heating, the platelets were irreversibly activated by the thrombin generated in the residual plasma. The mesh was cut into strips, which were mounted for recording tension. It contracted in response to aggregating agents and relaxed to antagonists. It contracted like clot retraction. Consisting almost entirely of platelets, it was more specific and the response showed a better reproducibility. It is a convenient tool for the study of physiological and biochemical studies of platelets and fibrinolytic agents.

Accession: 006173838

PMID: 2954373

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