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Preparation of scopoletin from cichoriin



Preparation of scopoletin from cichoriin



Herba Polonica 25(2): 133-136



A simple 2-stage synthesis was presented for scopoletin using cichoriin isolated from Cichorium intybus L. as a parent substance. Methylation of cichoriin resulted in scopolin, which was subsequently hydrolyzed to scopoletin in acidic medium. The glucoside moiety of cichoriin plays the role of a protective group during methylation. Yield of the proposed process is about 82%.

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Accession: 006173847

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