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Preparation of selenium containing aromatic and hetero cyclic c substituted alpha amino acetic acid derivatives of potential biomedical application


, : Preparation of selenium containing aromatic and hetero cyclic c substituted alpha amino acetic acid derivatives of potential biomedical application. Journal of Heterocyclic Chemistry 18(8): 1605-1608

Model Se-containing aromatic and heterocyclic C-substituted .alpha.-amino acid compounds were synthesized as potential biomedical organ scanning application (external imaging) agents for humans. The synthesis is based on the amidoalkylation of aromatic and heterocyclic compounds with .alpha.-hydroxyglyoxylic acid-primary amide adducts. The procedure is simple and straightforward, the overall yields were good and the method was apparently of general use for the preparation of a wide variety of Se-containing amino acids.

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