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Preparation of sodium cromoglycate intal labeled with isotopic hydrogen

Preparation of sodium cromoglycate intal labeled with isotopic hydrogen

Journal of Labelled Compounds & Radiopharmaceuticals 21(4): 363-374

Procedures for the labeling of the anti-allergic drug, sodium cromoglycate, with both 3H and 2H are described. Sodium [6,6',8,8'-2H]cromoglycate was prepared by acid catalyzed exchange with deuterosulfuric acid. The 2-2H and 2-3H isotopomers were prepared via borodeuteride and borotritide reductions of an oxo-precursor. Sodium [3,3'-3H]cromoglycate was prepared at high specific radioactivity by RhCl3 catalyzed exchange with high atom % abundance tritiated water.

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Accession: 006173878

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