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Preparation of soft dosage forms on a vaseline base for inoculation during detection of their microbial contamination and sterility






Khimiko-Farmatsevticheskii Zhurnal 15(5): 116-120

Preparation of soft dosage forms on a vaseline base for inoculation during detection of their microbial contamination and sterility

The antimicrobial effect of Tween-80 was studied with respect to the following microorganisms: Pseudomonas aeruginosa strain 47, Escherichia coli strain M-17, Staphylococcus aureus strain 209-P, Candida albicans, Sarcina lutea [Micrococcus luteus] strain 9341, Bacillus cereus strain 8035 and B. subtilis strain L-2. A method was proposed for preparing ointment samples by means of homogenization in aqueous medium (at a ratio of 1:10) using glass beads and 2.5% Tween-80 at a temperature of 40-42.degree. C for 5-15 min with subsequent sowing of the homogenate in liquid and agarized nutritive media.


Accession: 006173880



Related references

Wanandi, B.; Speiser, P., 1970: The microbial contamination of dosage forms and raw materials. Pharmaceutica Acta Helvetiae 45(8): 501-512

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