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Preparation of soft dosage forms on a vaseline base for inoculation during detection of their microbial contamination and sterility

Khimiko-Farmatsevticheskii Zhurnal 15(5): 116-120

Preparation of soft dosage forms on a vaseline base for inoculation during detection of their microbial contamination and sterility

The antimicrobial effect of Tween-80 was studied with respect to the following microorganisms: Pseudomonas aeruginosa strain 47, Escherichia coli strain M-17, Staphylococcus aureus strain 209-P, Candida albicans, Sarcina lutea [Micrococcus luteus] strain 9341, Bacillus cereus strain 8035 and B. subtilis strain L-2. A method was proposed for preparing ointment samples by means of homogenization in aqueous medium (at a ratio of 1:10) using glass beads and 2.5% Tween-80 at a temperature of C for 5-15 min with subsequent sowing of the homogenate in liquid and agarized nutritive media.

Accession: 006173880

Related references

Wanandi, B.; Speiser, P., 1970: The microbial contamination of dosage forms and raw materials. Pharmaceutica Acta Helvetiae 45(8): 501-512

De-Los-Angeles-Mosso-Romeo, M.; Arribas, M.L.G.; Ruiz, A.F.; Patier, R.F., 1977: Microbial contamination of alkaline pharmaceutical dosage forms and its control by chemical means. Pharmaceutical products which are not necessarily sterile and for oral administration were studied and the total number of aerobic bacteria fall within the values recommended by the international standards. This was not the case for fungus present...

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