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Preparation of some fatty glycolic acid derivatives and screening for anti microbial activity


Journal of the American Oil Chemists' Society 57(4): 139-141
Preparation of some fatty glycolic acid derivatives and screening for anti microbial activity
Nine glycolic acid derivatives were prepared and screened as primary plasticizers for polyvinyl chloride (PVC) and for antimicrobial activity. Two types of compounds were represented: those with a methyl or ethyl ester grouping at the carboxyl function of glycolic acid and a fatty acyl group at the hydroxyl function and those with 3 acyl groups attached at the hydroxyl functions of the amide, resulting from the reaction of glycolic acid and diethanolamine. None of the compounds was compatible with PVC at the 35% level of incorporation, and the compounds were not further evaluated as plasticizers. They were screened for antimicrobial activity against a gram-positive bacterium, Staphylococcus aureus; a gram-negative bacterium, Escherichia coli; a yeast, Candida utilis; and a mold, Penicillium sp. Six of the compounds inhibited 2 or more of the test organisms, suggesting that some of these materials merit further testing as biostatic agents.


Accession: 006173896



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