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Preparation of some fatty glycolic acid derivatives and screening for anti microbial activity

, : Preparation of some fatty glycolic acid derivatives and screening for anti microbial activity. Journal of the American Oil Chemists' Society 57(4): 139-141

Nine glycolic acid derivatives were prepared and screened as primary plasticizers for polyvinyl chloride (PVC) and for antimicrobial activity. Two types of compounds were represented: those with a methyl or ethyl ester grouping at the carboxyl function of glycolic acid and a fatty acyl group at the hydroxyl function and those with 3 acyl groups attached at the hydroxyl functions of the amide, resulting from the reaction of glycolic acid and diethanolamine. None of the compounds was compatible with PVC at the 35% level of incorporation, and the compounds were not further evaluated as plasticizers. They were screened for antimicrobial activity against a gram-positive bacterium, Staphylococcus aureus; a gram-negative bacterium, Escherichia coli; a yeast, Candida utilis; and a mold, Penicillium sp. Six of the compounds inhibited 2 or more of the test organisms, suggesting that some of these materials merit further testing as biostatic agents.

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