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Preparation of some hydrazones of conjugated styryl ketones and related compounds for evaluation principally as anti neoplastic agents


, : Preparation of some hydrazones of conjugated styryl ketones and related compounds for evaluation principally as anti neoplastic agents. Canadian Journal of Pharmaceutical Sciences 16(1): 1-7

A number of hydrazones derived from 1-phenyl-1-buten-3-one and 1-(3,4-dichlorophenyl)-1-nonen-3-one were prepared and evaluated for antheoplastic properties. 1-Phenyl-1-buten-3-one thiosemicarbazone had confirmed activity in the P388 [mouse lymphocytic leukemia cells] screen and it formed a 1:1 chelate with cupric ions. Pharmacological evaluation of these 2 series of compounds showed that certain of these hydrazones possesed analgesic, anti-inflammatory, antidepressant, anti-anaphylactic and antimicrobial activities. A series of chalcones were synthesized and had cytotoxic properties but did not achieve the criterion for activity in the P388 lymphocytic leukemia.

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