EurekaMag.com logo
+ Site Statistics
References:
48,253,228
Abstracts:
22,798,842
+ Resolve Accession
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
Submit PDF Full TextSubmit PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Preparation of spherical matrices of prolonged release drugs from liquid suspension


, : Preparation of spherical matrices of prolonged release drugs from liquid suspension. Journal of Pharmaceutical Sciences 70(8): 913-916

A simple and less expensive method for the preparation of spherical matrixes of prolonged-release drugs was developed from liquid suspension. The drugs dispersed in distilled water were agglomerated with a small amount of organic solution or melt of matrix material. The process, called a solution or melting method, depended on the state of matrix material. In the present study, sulfamethoxazole and sulfanilamide were agglomerated with white beeswax and ethylcellulose. The parameters affecting the average size and release behavior of the resultant matrixes were investigated. Increasing the amount of matrix material used yielded large matrixes and prolonged-release action. The drugs rendered hydrophobic by surface treatment produced larger matrixes that released drug more slowly than untreated drugs. The sizes of the matrixes decreased and became uniform with increasing agitation speed. The sulfamethoxazole matrixes with wax proved to be enteric coated as the release rat was fast in the alkaline test solution (pH 7.5) but slow in the acidic one (pH 1.2).

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006173940

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Cox, R. I.; Hoskinson, R. M.; Scaramuzzi, R. J.; Bindon, B. M.; George, J. M.; Wilson, P. A.; Hinks, N. T., 1980: Immunological control of ovulation. By immunisation of ewes with human serum albumin carrier linked to androstenedione or oestrogen, it was possible to increase ovulation rate by about 0.4 ovulations per sheep without producing anoestrus.

Allen, Mark-D; Buchberger, Alexander; Bycroft, Mark, 2006: The PUB Domain Functions as a p97 Binding Module in Human Peptide N-Glycanase. The AAA ATPase p97 is a ubiquitin-selective molecular machine involved in multiple cellular processes, including protein degradation through the ubiquitin-proteasome system and homotypic membrane fusion. Specific p97 functions are mediated by a va...

Criscoli, Alessandro E-mail: alecriscolifastwebnet.it.; Colloca, Francesco.; Carpentieri, Paolo.; Belluscio, Andrea.; Ardizzone, Giandomenico., 2006: Observations on the reproductive cycle, age and growth of the salema, Sarpa salpa (Osteichthyes: Sparidae) along the western central coast of Italy. The sexual maturation and the growth of the salema, Sarpa salpa (Linnaeus, 1758), along the Italian Mediterranean coast (central Italy), were Studied in fish (n = 105) killed incidentally by underwater explosions during the construction of Civitav...

Zhilyayeva V. A.; Kolesnikov L. V., 1967: Relation between the magnetic-viscosity coefficient, S (sub v) , and the properties of ferromagnetic grains. Physics of the Solid Earth 11: 738-743

Egan B.; Panis R.; Hinderliter A.; Schork N.; Julius S., 1987: Mechanism of increased alpha adrenergic vasoconstriction in human essential hypertension. Multiple components of vascular alpha adrenergic responsiveness were investigated in twenty-four men with mild hypertension and eighteen age- and weight-matched normotensive controls. Arterial plasma norepinephrine (paNE), an index of sympathetic...

Mai, W. F., 1951: Solanum Xanti Gray and Solarium integrifolium Poir., new hosts of the golden nematode, Heterodera rostochiensis Wollenweber. A method is described by which slight infestations of nematodes can be detected. Readings can thus be made without destroying the plant; the test is therefore valuable in breeding work. S. Xanti and S. integrifolium were both found to be hosts of...

Walker, A., 1983: The fate and significance of herbicide residues in soil. A brief account is given of processes influencing the residual life of a herbicide in the soil and of reasons why in general residue accumulation is not a problem. Herbicides are lost by physical removal of the unchanged molecule (volatilization,...

Arnold, G. W., 1966: The special senses in grazing animals. 1. Sight and dietary habits in sheep. Diets and productivity of sheep blinkered so that they could not see what they ate or unblinkered were compared in a number of experiments. Composition of diet differed between groups under some pasture conditions; the difference was attributed to...

Friedman, William E., 1993: Crossing the line Comparing female gametophytic structure, fertilization biology and endosperm development in primitive flowering plants and their outgroups. American Journal of Botany 80(6 SUPPL ): 123

Peterson P.; Sacks S., 1986: Fracture dislocation of the base of the fifth metacarpal associated with injury to the deep motor branch of the ulnar nerve a case report. Traumatic neuropraxia of the deep motor branch of the ulnar nerve after a fracture-dislocation of the fifth metacarpal is reported. Salient anatomy is discussed and the diagnostic tests necessary to identify this lesion are described. Residual eff...