+ Translate

Preparation of spherical matrices of prolonged release drugs from liquid suspension

, : Preparation of spherical matrices of prolonged release drugs from liquid suspension. Journal of Pharmaceutical Sciences 70(8): 913-916

A simple and less expensive method for the preparation of spherical matrixes of prolonged-release drugs was developed from liquid suspension. The drugs dispersed in distilled water were agglomerated with a small amount of organic solution or melt of matrix material. The process, called a solution or melting method, depended on the state of matrix material. In the present study, sulfamethoxazole and sulfanilamide were agglomerated with white beeswax and ethylcellulose. The parameters affecting the average size and release behavior of the resultant matrixes were investigated. Increasing the amount of matrix material used yielded large matrixes and prolonged-release action. The drugs rendered hydrophobic by surface treatment produced larger matrixes that released drug more slowly than untreated drugs. The sizes of the matrixes decreased and became uniform with increasing agitation speed. The sulfamethoxazole matrixes with wax proved to be enteric coated as the release rat was fast in the alkaline test solution (pH 7.5) but slow in the acidic one (pH 1.2).

(PDF 0-2 workdays service)

Order PDF Full Text


Click here to order any other PDF Full Text

Accession: 006173940

PMID: 7310663

Submit PDF Full Text: Here

Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:

Other references

Nesterenko, N. V., 1954: Experiment on the hybridization of Ural ripoussa with Lake Peipus whitefish. Established by hybridization that ripoussa acclimatized in Ural, and such deviates in morphology and growth rate from typical, are hybrids of ripoussa (Coregonus albula) and Peipus whitefish (C. lavaretus maraenoides), present in all Ural lakes wh...

Lusheng Wu,.; Xiaobing Wu,.; Hongxing Jiang,.; Chaolin Wang,, 2005: Habitat characteristics of wild Chinese alligator (Alligator sinensis). During 2002 and 2003, the habitat characteristics of wild Chinese alligator were studied in the National Nature Reserve for Chinese Alligator in the south of Anhui Province by collecting samples from among the 22 locations where wild Chinese allig...

Calderwood, W. L., 1931: Salmon hatching and Salmon migration. Unknown

Pavlov, A.S., 1962: On the problem of interstitial gamma ray therapy of malignant tumors with the aid of nylon tubes charged with radioactive cobalt (Co60). Khirurgiia 38: 144-150

Anonymous, 1977: Pros and cons of convenience food service systems. A system of using convenience foods to fulfill school food programs' requirements is described. The prohibitively high costs of renovating school kitchens coupled with space restrictions have made convenience foods a feasible solution to the...

Kamijo, Y.; Takeno, Y.; Sakai, A.; Inaki, M.; Okumoto, T.; Itoh, J.; Masuki, S.; Yanagidaira, Y.; Nose, H., 2000: Plasma lactate concentration and muscle blood flow during dynamic exercise with continuous negative pressure breathing. FASEB Journal 14(4): A325, March 15

Kimura, Jun, 1992: Advances in clinical neurophysiology Pathophysiology of central and peripheral demyelination. Neurophysiologie Clinique 22(SUPPL 1): 1S

Woodward, A. S., 1910: On a fossil Sole and a fossil Eel from the Eocene of Egypt. Geological Magazine London, 7 402-405

Foca, F.J.; Liebeskind, A.L., 1973: Osteopetrosis with arteritis: Case report and review of the literature. Archives of Physical Medicine and Rehabilitation 54(8): 370-372

Warner, P., 1999: Fire track: a unique fire management tool. Proceedings annual Forest Vegetation Management Conference: 0th) 12-14