Prevention and treatment of secondary disease part 1 effects of 3 nonspecific agents anti thymocyte serum antigen binding fragment extracted from anti thymocyte serum and thymic chalone

Mathe, G.; Halle-Pannenko, O.; Kiger, N.; Florentin, I.; Bourut, C.

International Journal of Radiation Oncology, Biology, Physics 1(5-6): 447-454

1976


ISSN/ISBN: 0360-3016
Accession: 006180053

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Abstract
Three non-specific agents, anti-thymocyte serum (ATS), antigen binding fragment extracted from anti-thymocyte serum (Fab fragment of ATS) and thymic chalone, known to inhibit acute graft-vs.-host (GVH) reaction, were compared for their efficacity in preventing or curing secondary disease induced by the transplantation of parental bone marrow and blood cells into LD100 irradiated F1 mice (preclinical model for studying clinical GVH). The agents were applied with the modalities usable in man: incubation with the cells to be grafted, and early or late administration to the recipients. Anti-thymocyte serum and Fab fragment increased neither the median survival time nor the percentage of long-term survivors, whatever the modality of administration. The thymic chalone incubated with the cells prior to grafting significantly increased the median survival time but not the percentage of long-term survivors. The early administration of thymic chalone to the recipient significantly increased the median survival time and the percentage of long-term survivors.