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Prevention of the lipid per oxidation activation and myo cardial anti oxidant system damage in stress and experimental infarction



Prevention of the lipid per oxidation activation and myo cardial anti oxidant system damage in stress and experimental infarction



Kardiologiya 21(12): 55-60



The multifold increase of intermediate products of lipid peroxidation, their hydroperoxides and terminate products of this process, Shiff's bases, occurred in rats with experimental myocardial infarction both in the ischemic and in nonischemic zones. Simultaneously, the activity of antioxidant enzymic systems was reduced in the myocardium. The superoxydismutase and catalase activities decreased insignificantly and the glutathione peroxidase activity was decreased by a factor of 2 . The preliminary adaptation of the animals to the periodic action of hypoxia itself did not influence the antioxidant systems of the organism, but it significantly decreased the accumulation of the lipid peroxidation products and the size of ischemic necrosis. Apparently, the protective effect of the adaptation to hypoxia during the ischemic damage is realized not by the increase of the antioxidant systems activity, but by the change in the membrane lipid composition.

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Accession: 006181279

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