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Prevention of ventricular fibrillation by dextro sotalol in a conscious canine model of sudden coronary death



Prevention of ventricular fibrillation by dextro sotalol in a conscious canine model of sudden coronary death



American Heart Journal 109(5 Part 1): 949-958



The antiarrhythmic and antifibrillatory actions of the d isomer of sotalol, administered in a multiple-dose regimen, were evaluated in conscious dogs 3 to 5 days after anterior myocardial infarction. The i.v. administration of d-sotalol, four 8 mg/kg doses over a 24-h treatment period, suppressed the induction of ventricular tachycardia by programmed electrial stimulation in 6 of 9 dogs tested, slowed the rate of the induced tachyarrhythmia in 2 of the remaining 3 dogs, and provided significant protection (5 of 8 d-sotalol vs. 0 of 8 vehicle control) against the development of ventricular fibrillation in response to ischemia at a site distant to a previous myocardial infarction. Increases in ventricular myocardial refractoriness and in QTc [computed QT interval] and paced QT intervals suggest that class III electrophysiologic actions contribute to the antiarrhythmic properties of d sotalol in this animal model. The degree of .beta.-adrenergic receptor blockade produced by d-sotalol in this dose regimen was negligible. The potential utility of d-sotalol in the prevention of ventricular tachycardia and ventricular fibrillation in the setting of myocardial infarction, particularly when .beta.-adrenergic receptor blockade is undesirable or contraindicated is suggested.

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Accession: 006181383

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