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Primary carcinoma of the trachea: combined small cell, squamous cell and giant cell carcinoma. Report of a case and a review of the literature



Primary carcinoma of the trachea: combined small cell, squamous cell and giant cell carcinoma. Report of a case and a review of the literature



Pathologica 78(1053): 99-105



Primary carcinoma of the trachea is a rare neoplasm whose incidence has not risen parallel with that of bronchial carcinoma (10, 12, 13), despite the fact that the trachea and bronchi are continuous structures. The mortality incidence from carcinoma of the trachea represents less than 0.1% of all cancer deaths (12). Approximately 500 cases of primary malignancy of the trachea have been described (3, 10, 12, 13). Squamous cell carcinoma is the most frequent type (47%), while primary small cell carcinoma is very unusual (12). We report a case of primary carcinoma of the trachea with a peculiar and unusual combined histologic pattern of small cell and squamous cell carcinoma with isolated bizarre giant cells, whose metastases in a regional lymph-node showed an anaplastic small cell carcinoma with numerous giant cells. To our knowledge, this is the second case of carcinoma of the trachea with this morphological pattern and the first case reported with macroscopic demonstration of the tumor.

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Accession: 006182509

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PMID: 3029656



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