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Primary per cutaneous vaccination

, : Primary per cutaneous vaccination. Journal of Infectious Diseases 135(1): 145-154

In an investigation of the antigenicity and reactogenicity of 4 smallpox vaccines, 786 children received primary percutaneous vaccination with vaccine in 1 of 3 concentrations, 106, 107 or 108 pock-forming units/ml. Dose-response curves indicated that the 3 licensed vaccines (New York City Board of Health strains grown in calf lymph or chorioallantoic membrane, and the Lister vaccine) had similar potencies, but the CV-1 strain was .apprx. 10-fold less infectious. CV-1 also produced smaller skin lesions than the other 3 vaccines, and the incidence of fever in CV-1 vaccinees who developed major reactions or serum antibody was not significantly different from that in children in all vaccine groups with no evidence of take. Hemagglutination-inhibiting antibody was consistently seen in individuals who received potent New York City and Lister vaccines, and neutralizing antibody was induced in 82%-85% of children in this group who had some evidence of take (production of hemagglutination-inhibiting antibody or major reaction). Only 30% of CV-1 vaccinees with takes produced neutralizing antibody. Minor complications occurred in all groups, but most often in children who received the New York City strains.

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