EurekaMag.com logo
+ Translate

Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine


, : Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine. Liver 4(4): 244-254

Ingestion of dimethylnitrosamine in a low dose and for a limited period by hamsters resulted in primary intrahepatic pyelophlebitis. The process began at 24 h and progressed within 2-4 wk to narrowing and, eventually, to partial obstruction of the portal bed. The lesions were characterized by endothelial necrosis followed by infiltrations of lymphoid cells extending into the portal tracts. Superficial lesions of terminal hepatic veins and parenchymal changes occurred only after a lapse of, respectively, 2 and 4 wk when restrictions of portal blood had been assumed. The parenchymal changes consisted of regional regenerative hyperplasia accompanied by subendothelial prolapse of hepatocytes into the wall of terminal veins. The lesions of the portal veins persisted for a prolonged period of time after the exposure to dimethylnitrosamine had ceased. These findings, associated with characteristic histological aspects, suggested seconary immune reaction following the initial toxic pylephlebitis. The possible relevance of the experimental results to understanding the nature of endemic portal venopathy in man is discussed with regard to pathogenesis and etiology.

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006184073

PMID: 6482685

DOI: 10.1111/j.1600-0676.1984.tb00934.x

Download PDF Full Text: Primary portal venopathy in the golden hamster treated with low doses of dimethylnitrosamine


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Virtanen, T.; Pihlanto, A.; Akkanen, S.; Korhonen, H., 2006: Development of antioxidant activity in milk whey during fermentation with lactic acid bacteria. To investigate the production of antioxidant activity during fermentation with commonly used dairy starter cultures. Moreover, to study the development of antioxidant activity during fermentation, and the connection to proteolysis and bacterial gr...

Brazier, M.A.B.; Finesinger, J.E.; CobbStanley, 1945: A contrast between the electroencephalograms of 100 psychoneurotic patients and those of 500 normal adults. The EEG of the psychoneurotic patients shows no gross abnormalities of wave pattern and in general falls within the normal range. Nevertheless, a study of the findings on a group of 100 psychoneurotic patients reveals that their electroencephalogr...

Anand, E.; Berggren, L.; Landry, J.; Tóth, Ágoston.; Detke, H.C., 2016: Clinical outcomes with olanzapine long-acting injection: impact of the 3-hour observation period on patient satisfaction and well-being. The objective of the present analysis is to determine the impact of the 3-hour observation period for olanzapine long-acting injection (LAI) on patient satisfaction and well-being by comparing data collected before and after its implementation. Th...

Feibelman, 1987: Force and total-energy calculations for a spatially compact adsorbate on an extended, metallic crystal surface. Physical Review. B, Condensed Matter 35(6): 2626-2646

Badr, H.S.; El-Hawy, M.A.; Helwa, M.A., 2016: P-Glycoprotein Activity in Steroid-Responsive vs. Steroid-Resistant Nephrotic Syndrome. To explore the expression of P-glycoprotein (P-gp) in the peripheral blood nucleated cells (PBNCs) of children with nephrotic syndrome in relation to their clinical response to glucocorticoid treatment. Thirty-six children with nephrotic syndrome...

Manke, J., 1974: How to rebuild animal housing for industrialized farming. Kooperation 8 (7) 312-315

Thai, H.Bao.Dieu.; Yu, J.Kyung.; Park, B.Sun.; Park, Y-Joon.; Min, S-Joon.; Ahn, D-Ro., 2016: A fluorogenic substrate of beta-lactamases and its potential as a probe to detect the bacteria resistant to the third-generation oxyimino-cephalosporins. We devised and synthesized a fluorogenic substrate of β-lactamases as a probe to detect the activity of the enzymes. Fluorescence of the probe emitted upon treatment of a β-lactamase and increased proportionally to the concentration of the enzym...

DEMPSEY.W.B.; SNELL.E.E., 1963: Pyridoxamine-Pyruvate Transaminase. Ii. Characteristics Of The Enzyme. Biochemistry 2: 1414-1419

ZETTLER, F., 1961: Aspects of operative treatment of obliterative vascular processes. Medizinische Klinik 56: 2124-2127

Carmichael, J.; Fergusson, R.J.; Wolf, C.R.; Balkwill, F.R.; Smyth, J.F., 1986: Augmentation of cytotoxicity of chemotherapy by human alpha-interferons in human non-small cell lung cancer xenografts. Three human non-small lung cancer xenograft lines were used to study the activity of combinations of cytotoxic drugs with human alpha-interferons (IFNs). Statistically significant potentiation of cis-platinum (CDDP) and cyclophosphamide (CY) given...