EurekaMag.com logo
+ Site Statistics
References:
52,725,316
Abstracts:
28,411,598
+ Search Articles
+ Subscribe to Site Feeds
EurekaMag Most Shared ContentMost Shared
EurekaMag PDF Full Text ContentPDF Full Text
+ PDF Full Text
Request PDF Full TextRequest PDF Full Text
+ Follow Us
Follow on FacebookFollow on Facebook
Follow on TwitterFollow on Twitter
Follow on Google+Follow on Google+
Follow on LinkedInFollow on LinkedIn

+ Translate

Primary radiation therapy for locally advanced breast cancer


Cancer 60(6): 1219-1225
Primary radiation therapy for locally advanced breast cancer
The optimal local-regional treatment for patients with Stage III breast cancer has not been determined. To evaluate the effectiveness of radiation therapy as local treatment for such patients, the results of 192 patients (five with bilateral disease) treated with radiation therapy without mastectomy between July 1, 1968 and December 31, 1981, were reviewed. Excisional biopsy (gross tumor removal) was performed in only 54 of the 197 breasts. Patients typically received 4500 to 5000 cGy in 5 weeks to the breast and draining lymph nodes; a local boost to areas of gross disease was delivered to 157 patients. Multi-agent chemotherapy was given to 53 patients. The median follow-up was 65 months. The acturial probability of survival for the entire group was 41% at 5 years and 23% at 10 years. The probability of relapse-free survival (RFS) was 30% at 5 years and 19% at 10 years. The addition of multi-agent chemotherapy was associated with a significantly improved 5-year RSF (40% versus 26%, P = 0.02). The 5-year survival rate was 51% for patients who received adjuvant multi-agent chemotherapy and 38% for patients who did not (P = 0.16). The acturial rate of local-regional tumor control (not censored for distal failure) for all patients was 73% at 5 years and 68% at ten years, and the crude incidence of local-regional control was 78%. Local-regional tumor control was principally influenced by radiation dose. Patients who received 6000 cGy or greater to the primary site had a better 5-year rate of control in the breast than did patients who received less than 6000 cGy (83% versus 70%, P = 0.06). Significant complications were seen in 15 patients (8%); these included moderate or severe arm edema in six patients and brachial plexopathy in four patients. Cosmetic results at last evaluation were excellent or good in 5% of evaluable patients, fair in 25%, and poor in 19%. It is concluded that high-dose radiation therapy without mastectomy is an effective means of controlling local-regional tumor in patients with locally advanced breast cancer.

Accession: 006184405

PMID: 3621108

DOI: 10.1002/1097-0142(19870915)60:6<1219::aid-cncr2820600610>3.0.co;2-2

Download PDF Full Text: Primary radiation therapy for locally advanced breast cancer



Related references

Treatment of locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery. Nci Monographs 1): 153-159, 1986

The management of nonmetastatic locally advanced breast cancer using primary induction chemotherapy with hormonal synchronization followed by radiation therapy with or without debulking surgery. World Journal of Surgery 9(5): 775-785, 1985

5-FU-docetaxel and concurrent radiation as salvage therapy after failure of neo-adjuvant chemotherapy for locally advanced primary breast cancer A faisability Study. Breast Cancer Research & Treatment 82(Supplement 1): S39-S40, 2003

High dose rate intra-operative radiation therapy for locally advanced/unresectable primary and locally recurrent rectal cancer. International Journal of Radiation Oncology Biology Physics 39(2 SUPPL ): 168, 1997

Management of locally advanced carcinoma of the breast by primary radiation therapy. International Journal of Radiation Oncology, Biology, Physics 9(3): 345-350, 1983

Postmastectomy radiation therapy in locally advanced breast cancer. Experimental Oncology 35(4): 258-266, 2014

The role of radiation therapy in locally advanced breast cancer. Breast Journal 16(2): 183-188, 2010

Primary chemotherapy and radiation therapy for locally advanced carcinoma of the breast: 15 Years of experience. Breast 6(5): 266-270, 1997

Radiation therapy in the management of locally advanced and disseminated breast cancer. Cancer 46(4 Suppl): 1075-1078, 1980

Preoperative 5-fluorouracil and radiation therapy for locally advanced breast cancer. American Journal of Surgery 174(6): 705-7; Discussion 707-8, 1997