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Primary response to poly l glutamic acid 60 l alanine 30 l tyrosine 10 in f 344 rats anti poly l glutamic acid 60 l alanine 30 l tyrosine 10 antibodies nonspecific immuno globulins and expression of the gat 13 idiotype

, : Primary response to poly l glutamic acid 60 l alanine 30 l tyrosine 10 in f 344 rats anti poly l glutamic acid 60 l alanine 30 l tyrosine 10 antibodies nonspecific immuno globulins and expression of the gat 13 idiotype. Cellular Immunology 80(1): 43-56

Antigen induces differentiation of 2 populations of Ig-containing cells: the 1st one to appear, IgCC, synthesizes nonspecific Ig and the 2nd, AbCC, synthesizes antibodies. Along with other arguments, the observation that nonspecific Ig bear idiotypic determinants, which cross-react with those of antibodies, had led to the hypothesis that IgCC are precursors of AbCC. The synthesis of such idiotype-positive nonspecific Ig before the appearance of the antibodies has not yet been proven. This problem was investigated by analyzing the primary response to poly(Glu60-Ala30-Tyr10) (GAT) in F344 rats. Kinetic studies of cells synthesizing Ig expressing a major idiotype (GAT-13), and of cells synthesizing Ig not expressing GAT-13 idiotype, revealed that these 2 cell populations were undetectable before the appearance of the anti-GAT antibodies. IgCC differentiation is not a necessary condition for the development of all antibody responses.

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