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Primary secondary and tertiary alpha alpha n di substituted alkylamines synthesis and pharmacology

, : Primary secondary and tertiary alpha alpha n di substituted alkylamines synthesis and pharmacology. European Journal of Medicinal Chemistry 12(4): 351-359

A series of primary secondary and tertiary alkylamines, .alpha.,.alpha.-disubstituted, saturated or unsaturated, were prepared. The 2 most common syntheses were Ritter's reaction on tertiary alkanols and Hofman's degradation reaction on .alpha.,.alpha.:disubstituted alkylamides. The pharmacological study with rats gave clear indication of an antiparkinsonian activity. They showed a common profile characterized by an inhibitory action of the neuroleptic and reserpinic catatonia and a lack of cholinolytic properties. A comparison made between dipropyl-1,1 butylamine and other parkinsonians (L-dopa, apomorphine, amphetamine and particularly amantadine), showed the former to be the most active product.

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Rateitschak, K.H., 1994: Failure of periodontal treatment. Treatment failures appear to occur more frequently in periodontology than in other dental disciplines. Inappropriate patient selection, incomplete diagnostic procedures, errors in diagnosis or prognosis, treatment difficulties, unsupervised healin...

Hayne, D.; Brown, R.S.; McCormack, M.; Quinn, M.J.; Payne, H.A.; Babb, P., 2002: Current trends in colorectal cancer: site, incidence, mortality and survival in England and Wales. The objective was to examine trends in colorectal cancer (CRC) incidence and mortality in England and Wales over the last 30 years. Age-standardized incidence, mortality and survival rates for CRC, based on data from the National Cancer Intelligen...

Ostrowski, J., 2007: Molecular medicine of the future--applications and pitfalls. Acta Poloniae Pharmaceutica 63(5): 329-332

Metelitsa, V.I., 1997: The outlook for gene therapy in cardiology. Terapevticheskii Arkhiv 69(2): 71-76

Brannan T.S., 1974: Hexo kinase in rat kidney nephron. Pharmacologist: 200

TSUKAMURA, M., 1961: Inhibition of deoxyribonucleic acid synthesis and change of cell surface character in the absence of streptomycin in streptomycin-dependent mutants of a Mycobacterium (Jucho). Journal of Antibiotics 14: 309-311

L.G.rche, Aé.; Burns, A.T.; D'Hooge, J.; Macisaac, A.I.; Heidbüchel, H.; Prior, D.L., 2012: Exercise strain rate imaging demonstrates normal right ventricular contractile reserve and clarifies ambiguous resting measures in endurance athletes. The significance of reduced right ventricular (RV) deformation reported in endurance athletes (EAs) is unclear, highlighting the ambiguities between physiologic RV remodeling and pathology. The aim of this study was to test the hypothesis that RV...

Kamau, E.; Alemayehu, S.; Feghali, K.C.; Juma, D.W.; Blackstone, G.M.; Marion, W.R.; Obare, P.; Ogutu, B.; Ockenhouse, C.F., 2015: Sample-ready multiplex qPCR assay for detection of malaria. Microscopy and antigen detecting rapid diagnostic tests are the diagnostic tests of choice in management of clinical malaria. However, due to their limitations, the need to utilize more sensitive methods such as real-time PCR (qPCR) is evident as...

Brock, C.D.; Ornstein, S.M.; Litchfield, L., 1986: An improved technique for Papanicolaou smear sampling in postmenopausal women. Journal of Family Practice 22(6): 498, 500-498, 500

Faigel, H.C., 1969: Reported patterns of venereal diseases in adolescents. Clinical Pediatrics 8(11): 620-620