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Primary stages of thrombin clearance and liver and lung absorption of complex heparin compounds in experimental depression of the function of the anti coagulation system and during its restoration in animals


, : Primary stages of thrombin clearance and liver and lung absorption of complex heparin compounds in experimental depression of the function of the anti coagulation system and during its restoration in animals. Vestnik Moskovskogo Universiteta Seriya VI Biologiya Pochvovedenie 31(4): 20-28

The delay of primary stages of the clearance of thrombin-I131 was found in systemic circulation of rats by experimental depression of the anticoagulating system as a consequence of a chronic atherogenic diet. This phenomenon was explained by a decrease of the complex heparin - thrombin-I131 and diminished absorption in the liver. The stimulation of formation of complex heparin-thrombin-I131 and its clearance were established after recovery of functional state of anticoagulating system in rats by the prolonged therapeutical use of the preparation, Linetol together with vitamin A. At the same time the intensification of accumulation of this complex in liver was detected. The appearance of heparin, protein and amine complexes and their absorption in the lungs were discovered after i.v. injection of thrombin-I131.


Accession: 006184671

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Related references

Kudryashev, B.; Ul'-Yanov, A.; Bazaz'-Yan, G.; Lyapina, L.; Systina, N., 1976: Initial stages of thrombin clearance and absorption of complex heparin compounds in the liver and lungs in the presence of experimental depression of anticlotting system functions and during functional restoration of this system in animals. Moscow University biological sciences bulletin: ransl 1976), 31 (3 4) 78-84

Kudryashov, B.A.; Bazaz'yan, G.G.; Lyapina, L.A.; Ul'yanov, A.M.; Sytina, N.P., 1977: The importance of heparin in thrombin iodine 131 clearance and complex formation processes in animals under experimental restoration of the anti coagulation system. Thrombin-131I infusion to rats receiving Linetol with vitamin A in the presence of both natural and atherogenic diets accelerated the clearance of thrombin-131I and elevated the level of nonenzymatic fibrinolysis in the blood and tissue of the liv...

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Kudriashov, B.A.; Bazaz'ian, G.G.; Liapina, L.A.; Ul'ianov, A.M.; Sytina, N.P., 1977: Importance of heparin in thrombin-131I clearance and in the complex formation processes in animals under experimental restoration of the function of the anticoagulating system. Thrombine-I131 infusion to animals receiving Linethol with vitamin A in the presence of both natural and atherogenic diets accelerated the clearance of thrombine-I131 and elevated the level of nonenzymatic fibrinolysis in the blood and tissue of t...

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Kudryashov, B.A.; Lyapina, L.A.; Ul'yanov, A.M.; Kovaleva, T.N., 1974: The role of a thrombin heparin complex formation at primary stages of thrombin clearance in the blood stream and the role of the liver and lungs in this process. The 1st stages of clearance of thrombin 131I in the blood of adult rats after i.v. administration were studied. I.v. injection of heparin prior to the thrombin injection accelerates formation of the nonenzymatic solvents of the nonstabilized fibri...

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Pastorova V.E.; Bazaz'yan G.G.; Romanovskii A.A., 1980: Anti thrombin iii level during intra venous injection of tissue thromboplastin and heparin in rats with depression of the function of the blood anti coagulation system induced by atherogenic diet. Rats with depressed function of the blood anticoagulation system due to an atherogenic diet had a slightly reduced level of antithrombin III by the 6th mo. of the diet as compared to the indices of control animals. I.v. injection of tissue thrombo...

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