EurekaMag.com logo
+ Translate

Primary structure of human carcinoembryonic antigen cea deduced from complementary dna sequence


, : Primary structure of human carcinoembryonic antigen cea deduced from complementary dna sequence. Biochemical & Biophysical Research Communications 142(2): 511-518

The cDNAs corresponding to the mRNA encoding a polypeptide which is immunoreactive with the antisera specific to carcinoembryonic antigen (CEA) (1) are cloned. The amino acid sequences deduced from the nucleotide sequences of the cDNAs show that it is synthesized as a precursor with a signal peptide followed by 668 amino acids of the putative mature CEA peptide, whose N-terminal 24 amino acids and amino acids 286 to 295 exactly coincide with those known for N-terminal sequences of CEA (2) and NFA-1 (3), respectively. The first 108 N-terminal residues are followed by three very homologous repetitive domains of 178 residues each and then by 26 mostly hydrophobic residues which probably comprise a membrane anchor. Each repetitive domain contains 4 cysteines at precisely the same positions and as many as 28 possible N-glycosylation sites are found in the CEA peptide region agreeing with high carbohydrate content of purified CEA.

(PDF 0-2 workdays service)

Order PDF Full Text

Close
Close

Click here to order any other PDF Full Text


Accession: 006184907

PDF Full Text: Submit


Submit PDF Full Text

No spam - Every submission is manually reviewed

Due to poor quality, we do not accept files from Researchgate

Submitted PDF Full Texts will always be free for everyone
(We only charge for PDFs that we need to acquire)

Select a PDF file:
Close
Close

Other references

Petkov, K.; Rusinov, K., 1967: Results of a trial of raspberry varieties and elites in the foothills of northern Bulgaria. Of seven varieties tested in 1959-64, Newburg and Balgarski Rubin were distinguished by high yield and high quality fruit. The former had a higher fruit yield than the latter but Balgarski Rubin ripened 6-8 days earlier.

Hulbert Shearon, T. E.; Wolfe, R. A.; Held, P. J., 1997: False positives and false negatives in measurement of standardized mortality ratio. Journal of the American Society of Nephrology 9(PROGRAM AND ABSTR ISSUE): 194A-195A, Sept

Zukal, R., 1968: Amphyosemion calliurum calliurum. Tropical Fish Hobbyist, 16(5): 16-21

Zanta, Maria Antonietta; Belguise Valladier, Pascale; Behr, Jean Paul, 1999: Gene delivery: a single nuclear localization signal peptide is sufficient to carry DNA to the cell nucleus. The use of a chemically controlled pathway to irreversibly link a single nuclear localization signal (NLS)-peptide to one end of a gene is reported. A capped 3.3 kb CMVLuciferase-NLS gene containing a single NLS peptide was generated. Transfecti...

Maccarro, J. B. A.; Gigante, J.; Garcia, M. H., 1983: Body measurements of the Andalusian horse. For 262 Andalusian stallions and 291 Andalusian mares, height at withers averaged 155.7 and 153.3 cm resp., height at the tail head 142.2 and 140.2 cm, chest diameter 154.5 and 153.0 cm, width of forehead 21.03 and 20.50 cm, and width of cranium 1...

Hase, A., 1942: Bait Experiments with Clothes Moths. Experiments were carried out in 1938-40 to investigate a claim that the powdered dried flowers of Helichrysum arenarium, which are known as Flores Stoechados and are used in medicine, attract clothes moths . Pieces of woollen material bearing smal...

Hubert P., 1990: Assessment of life long risk in the analyses of unscear beir and icrp. During the last two years, international committees dealing with the effects of ionizing radiation have published a new series of risk estimates. New epidemiological data, in particular in the case of A-bomb survivors whose doses have been reasses...

Scharrer, K.; Seibel, W., 1956: The effect of nutrients and light intensity on the nitrate content of fodder crops.. Increasing N supply up to a certain maximum increased yields and concentrations of nitrate-N and crude protein-N in fodder crops in sand cultures; high N depressed yields and resulted in maximum values of 15 mg nitrate-N/g dry matter in ryegrass,...

Jose, L.; Patel, R. J., 1991: An ecological study of algae in the central waste water treatment plant cwwtp of indian petrochemical corporation ltd. ipcl baroda india. The ecology of algae in the CWWTP of IPCL was studied. An algal community dominated by members of Cyanophyceae, Chlorophyceae and Bacillariophyceae were found.

Torrezan, R.; Pagliarini, M. S.; Corazza Nunes, M. J.; Silva, N., 1995: Prophase II as a proof of chiasma terminalization through heterochromatin in maize. Analysis of heteromorphic bivalents of the Brazilian maize cultivars Ag303 and Axteca for bands during the diplotene and diakinesis phases showed that, although chiasma terminalization occurred, the chiasma were unable to go beyond the heterochrom...