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Production and study of experimental diabetes in mice with alloxan

Production and study of experimental diabetes in mice with alloxan

Indian Journal of Pathology & Microbiology 25(1): 1-5

Experimental diabetes was produced in mice using different doses of alloxan. Mortality was minimal (10-15%) with 75 mg/kg and diabetes was produced in 70-90% animals by the 3rd-7th day after alloxan administration. Normal blood sugar in the strain of mice used ranged between 60-160 mg%. Mean blood sugar level of alloxan treated mice was 495.04, 498.11 and 458.80 mg% of the 3rd, 5th and 7th days after injection, respectively. Varying degree of atrophy was seen in all sections of pancreas studied. Hydropic degeneration of varying severity was seen in 93.3% of the cases and extensive necrosis of islets of pancreas in 20% of the cases. No positive correlation was seen between the blood sugar level and the extent of histopathological changes in pancreas.

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Accession: 006190398

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PMID: 7106904

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