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Programmed cell death in the muellerian duct induced by muellerian inhibiting substance

Programmed cell death in the muellerian duct induced by muellerian inhibiting substance

American Journal of Anatomy 149(3): 353-376

The importance of a secretory product of the fetal testis, Muellerian inhibiting substance [MIS] in determining the fate of the Muellerian duct in the developing male fetus was well documented. The mechanism of action of MIS in the male rat fetus during the course of Muellerian duct degeneration was examined. The action of MIS mimics the general morphogenetic phenomenon of programmed cell death, although important differences were found compared to the majority of other studies of cell death. The initial morphological event in the degenerating Muellerian duct was an increase in lysosomes within duct cells. Following loss of polarity and orientation, the duct cells were subsequently removed by invading macrophages from surrounding mesenchyme. Concommitant with differentiation of these macrophages, the adjacent mesenchyme assumed a characteristic whorled pattern around the degenerating Muellerian duct. Cytochemical localization of acid phosphatase confirmed the presence of newly formed lysosomes within Muellerian duct cells and then within cytoplasm of invading macrophages.

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Accession: 006196834

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